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Plasma taurine concentrations and M-mode echocardiographic measures in healthy cats and in cats with dilated cardiomyopathy.
|Title||Plasma taurine concentrations and M-mode echocardiographic measures in healthy cats and in cats with dilated cardiomyopathy.|
|Publication Type||Journal Article|
|Year of Publication||1991|
|Authors||Sisson DD, Knight DH, Helinski C, Fox PR, Bond BR, Harpster NK, Moise NS, Kaplan PM, Bonagura JD, Czarnecki G|
|Journal||Journal of veterinary internal medicine / American College of Veterinary Internal Medicine|
|Date Published||1991 Jul-Aug|
|Keywords||Animals, Body Weight, Cardiomyopathy, Dilated, Cat Diseases, Cats, Echocardiography, Female, Male, Regression Analysis, Taurine|
M-mode echocardiography was completed and plasma taurine concentrations were determined in 79 healthy cats and 77 cats with dilated cardiomyopathy (DCM). In healthy cats, a relationship was not observed between plasma taurine concentrations and any M-mode echocardiographic measurement. End-systolic and end-diastolic cardiac chamber dimensions were larger; wall thickness measures were smaller; and calculations of fractional shortening were less in cats with DCM than in healthy cats. Plasma taurine concentrations less than 30 nmol/mL were detected in 7/79 healthy cats and in 52/77 cats with DCM. Of the 52 cats with DCM and an initial plasma taurine concentration less than 30 nmol/mL, 23 died or were euthanized during the first post-treatment week, 7 were lost to further study, and 22 improved after taurine supplementation. Of the 25 cats with DCM and an initial plasma taurine concentration greater than or equal to 30 nmol/mL, 9 died or were euthanatized during the first post-treatment week, and 9 were lost to further study. Two cats did not improve, of which one died and one was euthanatized 4 to 8 weeks after initiation of taurine supplementation. Five cats with a plasma taurine concentration greater than or equal to 30 nmol/mL improved after taurine supplementation. Myocardial function subsequently deteriorated in three of these cats. Two of the three cats had signs of congestive heart failure redevelop.
|Alternate Journal||J. Vet. Intern. Med.|