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Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.
|Title||Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Cupit PM, Steinauer ML, Tonnessen BW, Eric Agola L, Kinuthia JM, Mwangi IN, Mutuku MW, Mkoji GM, Loker ES, Cunningham C|
|Journal||International journal for parasitology|
|Date Published||2011 Oct|
|Keywords||Alleles, Animals, Antigens, Helminth, Humans, Kenya, Male, Mutation, Missense, Point Mutation, Polymorphism, Genetic, Schistosoma mansoni, Tetraspanins, Vaccines|
A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya.
|Alternate Journal||Int. J. Parasitol.|