Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.

TitlePolymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.
Publication TypeJournal Article
Year of Publication2011
AuthorsCupit PM, Steinauer ML, Tonnessen BW, Eric Agola L, Kinuthia JM, Mwangi IN, Mutuku MW, Mkoji GM, Loker ES, Cunningham C
JournalInternational journal for parasitology
Volume41
Issue12
Pagination1249-52
Date Published2011 Oct
ISSN1879-0135
KeywordsAlleles, Animals, Antigens, Helminth, Humans, Kenya, Male, Mutation, Missense, Point Mutation, Polymorphism, Genetic, Schistosoma mansoni, Tetraspanins, Vaccines
Abstract

A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya.

DOI10.1016/j.ijpara.2011.07.007
Alternate JournalInt. J. Parasitol.