Preliminary study of the pharmacokinetics and toxicopathy of deoxynivalenol (vomitoxin) in swine.

TitlePreliminary study of the pharmacokinetics and toxicopathy of deoxynivalenol (vomitoxin) in swine.
Publication TypeJournal Article
Year of Publication1985
AuthorsCoppock RW, Swanson SP, Gelberg HB, Koritz GD, Hoffman WE, Buck WB, Vesonder RF
JournalAmerican journal of veterinary research
Volume46
Issue1
Pagination169-74
Date Published1985 Jan
ISSN0002-9645
KeywordsAnimal Feed, Animals, Female, Foodborne Diseases, Sesquiterpenes, Swine, Swine Diseases, Tissue Distribution, Trichothecenes
Abstract

Study was made of the pharmacokinetics and toxicopathy of deoxynivalenol (DON, vomitoxin) given IV to swine. In the 24 hours after swine were given DON, clinical signs of vomiting, diarrhea, muscular weakness, tremors, and twilight coma were similar to those observed with other 12,13-epoxytrichothecenes. Hypoglycemia and pancreatic islet cell lesions were observed which indicated that DON-induced changes in intermediary metabolism may be an insidious aspect of DON intoxication. Histopathologic examination of all organ systems revealed pancreatic acinar and islet cell necrosis and mild lympholysis of the mesenteric lymph nodes. The renal excretion of DON was altered by IV infusion of saline solution. Pharmacokinetic findings may indicate that DON was both secreted and reabsorbed by the renal tubules. The half-life of DON ranged from 2.08 to 3.65 hours. Residues of DON were not found in skeletal muscle of swine at 24 hours after dosing.

Alternate JournalAm. J. Vet. Res.