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Primary ureteral giant cell sarcoma in a Pomeranian.
|Title||Primary ureteral giant cell sarcoma in a Pomeranian.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Rigas JD, Smith TJ, Gorman EM, Valentine BA, Simpson JM, Seguin B|
|Journal||Veterinary clinical pathology / American Society for Veterinary Clinical Pathology|
|Date Published||2012 Mar|
|Keywords||Animals, Dog Diseases, Dogs, Male, Sarcoma, Ureteral Neoplasms|
An 8-year-old male neutered Pomeranian dog was presented to the Veterinary Teaching Hospital at Oregon State University for surgical treatment of hydronephrosis of the left kidney and a left cranial abdominal mass. A primary ureteral mass was found during exploratory surgery, and the mass was resected and ureteral anastomosis was performed. Cytologic evaluation of the mass revealed 3 distinct cell populations, including a large number of multinucleated giant cells, a moderate number of thin spindle-shaped cells, and cohesive clusters of transitional epithelial cells. The cytologic diagnosis was giant cell sarcoma. The diagnosis was confirmed by histologic examination, and immunohistochemical staining was performed. The spindle-shaped cells and multinucleated giant cells were both immunoreactive for vimentin and spindle-shaped cells for S-100. Tumor cells did not express wide-spectrum cytokeratin, broad-spectrum muscle actin, smooth muscle actin, sarcomeric actin, desmin, BLA36, Mac 387, synaptophysin, neuron-specific enolase, glial fibrillary acid protein, or von Willebrand factor. These findings are most consistent with an anaplastic sarcoma with giant cells. This is the first case report of a primary ureteral giant cell sarcoma in a dog.
|Alternate Journal||Vet Clin Pathol|