Protein-losing enteropathy in dogs is associated with decreased fecal proteolytic activity.

TitleProtein-losing enteropathy in dogs is associated with decreased fecal proteolytic activity.
Publication TypeJournal Article
Year of Publication2004
AuthorsRuaux CG, Steiner JM, Williams DA
JournalVeterinary clinical pathology / American Society for Veterinary Clinical Pathology
Volume33
Issue1
Pagination20-2
Date Published2004
ISSN0275-6382
Keywordsalpha 1-Antitrypsin, Animals, Caseins, Dog Diseases, Dogs, Exocrine Pancreatic Insufficiency, False Positive Reactions, Feces, Protein-Losing Enteropathies
Abstract

Measurement of proteolytic activity in feces is a traditional method for the diagnosis of exocrine pancreatic insufficiency (EPI). A drawback of this method is the occurrence of falsely low results that may lead to a false-positive diagnosis of EPI. We hypothesized that intestinal loss of serum proteinase inhibitors in protein-losing enteropathy (PLE) may inhibit fecal proteolytic activity and be a potential source of false low results.

Alternate JournalVet Clin Pathol