Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease.

TitleRandomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease.
Publication TypeJournal Article
Year of Publication2008
AuthorsBaltzer WI, McMichael MA, Hosgood GL, Kerwin SC, Levine JM, Steiner JM, Ruaux CG
JournalSpine
Volume33
Issue13
Pagination1397-402
Date Published2008 Jun 1
ISSN1528-1159
KeywordsAcetylcysteine, Animals, Antioxidants, Biological Markers, Dinoprost, Disease Models, Animal, Dog Diseases, Dogs, Female, Infusions, Intravenous, Intervertebral Disk, Intervertebral Disk Displacement, Laminectomy, Male, Oxidative Stress, Random Allocation, Spinal Cord Injuries, Time Factors
Abstract

The effect of N-acetylcysteine administration intravenously before hemilaminectomy surgery on neurologic outcome and 15F 2t isoprostane excretion in dogs was examined in a blinded, placebo-controlled trial.

DOI10.1111/j.1365-3164.2011.00980.x
Alternate JournalSpine