The relationship between endogenous cortisol, blood micronutrients, and neutrophil function in postparturient Holstein cows.

TitleThe relationship between endogenous cortisol, blood micronutrients, and neutrophil function in postparturient Holstein cows.
Publication TypeJournal Article
Year of Publication2003
AuthorsCebra CK, Heidel JR, Crisman RO, Stang BV
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume17
Issue6
Pagination902-7
Date Published2003 Nov-Dec
ISSN0891-6640
KeywordsAnimals, Cattle, Cell Adhesion, Copper, Cytochromes c, Female, Hydrocortisone, Lactation, Micronutrients, Milk, Neutrophils, Postpartum Period, Selenium, Statistics, Nonparametric, Superoxides, Zinc
Abstract

Neutrophil function, blood micronutrients, and cortisol concentrations were measured in 43 clinically healthy postparturient Holstein cows. Estimated 305-day mature equivalent milk production and neutrophil function were related to results of the blood micronutrient concentrations and neutrophil function tests. Cattle had low to normal zinc concentrations; normal to high selenium, vitamin E, and cortisol concentrations; and normal copper concentrations. Blood selenium (P = .03) and zinc (P = .027) concentrations were both significant predictors of neutrophil adhesion, and selenium (P < .001) was a significant predictor of neutrophil cytochrome C reduction (superoxide production). Fourteen of 20 (70%) cattle with blood selenium concentrations > 300 ng/mL had neutrophil adhesion, and 15 of 20 (75%) had cytochrome C reduction above the mean value for this group. There was also a significant correlation (r = 0.331; P = .037) between cytochrome C reduction and estimated milk production. These findings suggest that neutrophils from postparturient dairy cows with higher blood concentrations of selenium have greater potential to kill microbes, and that cattle with greater superoxide production may have higher milk production.

Alternate JournalJ. Vet. Intern. Med.