Resistance mechanisms matter in SIR models.

TitleResistance mechanisms matter in SIR models.
Publication TypeJournal Article
Year of Publication2007
AuthorsReluga TC, Medlock J
JournalMathematical biosciences and engineering : MBE
Date Published2007 Jul
KeywordsCommunicable Diseases, Disease Outbreaks, Disease Susceptibility, Humans, Immunity, Innate, Incidence, Models, Immunological, Population Dynamics, Risk Assessment, Risk Factors, Switzerland

We compare four SIR-style models describing behavioral or immunological disease resistance that may be both partial and temporary in parameter regions feasible for interpandemic influenza. For the models studied, backward bifurcations and bistability may occur in contexts where resistance is due to behavior change, but they do not occur when resistance originates from an immune response. Care must be exercised to ensure that modeling assumptions about resistance are consistent with the biological mechanisms under study.

Alternate JournalMath Biosci Eng