Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis.

TitleSecreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis.
Publication TypeJournal Article
Year of Publication2010
AuthorsDanelishvili L, Yamazaki Y, Selker J, Bermudez LE
JournalPloS one
Volume5
Issue5
Paginatione10474
Date Published2010
ISSN1932-6203
KeywordsAmino Acid Sequence, Animals, Apoptosis, Bacterial Proteins, Cell Line, Cell Survival, DNA Transposable Elements, Genetic Complementation Test, Genetic Testing, Humans, Macrophages, Mice, Molecular Sequence Data, Mutation, Mycobacterium tuberculosis, Necrosis, Phenotype, RNA, Small Interfering, Signal Transduction, Transfection, Tuberculosis, Tumor Necrosis Factor-alpha
Abstract

Inhibition of macrophage apoptosis by Mycobacterium tuberculosis has been proposed as one of the virulence mechanisms whereby the pathogen avoids the host defense. The mechanisms by which M. tuberculosis H37Rv strain suppress apoptosis and escapes human macrophage killing was investigated.

DOI10.1111/j.1365-3164.2011.00980.x
Alternate JournalPLoS ONE