Short communication: impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia.

TitleShort communication: impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia.
Publication TypeJournal Article
Year of Publication2005
AuthorsKyelem D, Medlock J, Sanou S, Bonkoungou M, Boatin B, Molyneux DH
JournalTropical medicine & international health : TM & IH
Volume10
Issue10
Pagination1002-4
Date Published2005 Oct
ISSN1360-2276
KeywordsAnimals, Burkina Faso, Elephantiasis, Filarial, Endemic Diseases, Filaricides, Humans, Ivermectin, Mansonella, Mansonelliasis, Microfilaria, Onchocerciasis, Population Surveillance, Prevalence, Rural Health, Time Factors, Wuchereria bancrofti
Abstract

Ivermectin has been and continues to be extensively used to control onchocerciasis in areas of hyper and mesoendemicity within the African Programme of Onchocerciasis Control. As programmes to eliminate lymphatic filariasis (LF) caused by Wuchereria bancrofti expand, areas of coendemicity with onchocerciasis will be incorporated into LF programmes. This study reports that in villages which were hyperendemic for onchocerciasis after some 14 years of treatment with ivermectin, no W. bancrofti could be detected in a population of 1210 individuals whilst in adjacent villages a prevalence of around 3% was found. Despite the long period of ivermectin treatment Mansonella perstans did not appear to respond to ivermectin in this setting.

DOI10.1111/j.1365-3156.2005.01489.x
Alternate JournalTrop. Med. Int. Health