A subinhibitory concentration of clarithromycin inhibits Mycobacterium avium biofilm formation.

TitleA subinhibitory concentration of clarithromycin inhibits Mycobacterium avium biofilm formation.
Publication TypeJournal Article
Year of Publication2004
AuthorsCarter G, Young LS, Bermudez LE
JournalAntimicrobial agents and chemotherapy
Volume48
Issue12
Pagination4907-10
Date Published2004 Dec
ISSN0066-4804
KeywordsAcquired Immunodeficiency Syndrome, Anti-Bacterial Agents, Aza Compounds, Azithromycin, Biofilms, Clarithromycin, Humans, Microbial Sensitivity Tests, Microscopy, Electron, Scanning, Mycobacterium avium Complex, Mycobacterium avium-intracellulare Infection, Quinolines
Abstract

Mycobacterium avium causes disseminated infection in immunosuppressed individuals and lung infection in patients with chronic lung diseases. M. avium forms biofilm in the environment and possibly in human airways. Antibiotics with activity against the bacterium could inhibit biofilm formation. Clarithromycin inhibits biofilm formation but has no activity against established biofilm.

DOI10.1128/AAC.48.12.4907-4910.2004
Alternate JournalAntimicrob. Agents Chemother.