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Therapeutic effects of paclitaxel-containing ultrasound contrast agents.
|Title||Therapeutic effects of paclitaxel-containing ultrasound contrast agents.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Tartis MS, McCallan J, Lum AFH, LaBell R, Stieger SM, Matsunaga TO, Ferrara KW|
|Journal||Ultrasound in medicine & biology|
|Date Published||2006 Nov|
|Keywords||Animals, Antineoplastic Agents, Phytogenic, Cell Death, Chick Embryo, Chorioallantoic Membrane, Contrast Media, Drug Carriers, Drug Delivery Systems, Humans, Integrin alphaVbeta3, Ligands, Melanoma, Microbubbles, Neoplasm Proteins, Paclitaxel, Sonication, Tumor Cells, Cultured|
Drug delivery vehicles that combine ultrasonic and molecular targeting are shown to locally concentrate a drug in a region-of-interest. The drug delivery vehicles, referred to as acoustically active lipospheres (AALs), are microbubbles surrounded by a shell of oil and lipid. In a region limited to the focal area of ultrasound application, circulating AALs are deflected by radiation force to a vessel wall and can subsequently be fragmented. Ligands targeting the alphavbeta3 integrin are conjugated to the AAL shell and increase in vitro binding by 26.5-fold over nontargeted agents. Toxicity assays demonstrate that paclitaxel-containing AALs exert a greater antiproliferative effect after insonation than free paclitaxel at an equivalent concentration. Lastly, ultrasound and molecular targeting are combined to deliver a model drug to the endothelium and interstitium of chorioallantoic membrane vasculature in vivo.
|Alternate Journal||Ultrasound Med Biol|