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Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice.
|Title||Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Bermudez LE, Reynolds R, Kolonoski P, Aralar P, Inderlied CB, Young LS|
|Journal||Antimicrobial agents and chemotherapy|
|Date Published||2003 Aug|
|Keywords||Animals, Anti-Bacterial Agents, Aza Compounds, Colony Count, Microbial, Drug Therapy, Combination, Fluoroquinolones, Humans, Liver, Mice, Mice, Inbred C57BL, Microbial Sensitivity Tests, Mycobacterium avium Complex, Mycobacterium avium-intracellulare Infection, Quinolines, Spleen, Thioacetazone|
In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 micro g/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens. A combination of SRI-286 and moxifloxacin was significantly more active than single drug regimens in liver and spleen.
|Alternate Journal||Antimicrob. Agents Chemother.|