Tp53 expressing squamous cell carcinoma of the tonsil in a captive polar wolf (Canis lupus arctos).

TitleTp53 expressing squamous cell carcinoma of the tonsil in a captive polar wolf (Canis lupus arctos).
Publication TypeJournal Article
Year of Publication2005
AuthorsTeifke JP, Löhr CV, Langner C
JournalJournal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
Volume36
Issue3
Pagination538-42
Date Published2005 Sep
ISSN1042-7260
KeywordsAnimals, Carcinoma, Squamous Cell, Fatal Outcome, Lymphatic Metastasis, Male, Palatine Tonsil, Tonsillar Neoplasms, Tumor Suppressor Protein p53, Wolves
Abstract

The gross and histopathologic findings for a primary tonsillar squamous cell carcinoma in a captive 11-yr-old male polar wolf (Canis lupus arctos) are described. The carcinoma had metastasized to regional lymph nodes of the pharynx, the precardial mediastinum, and the lungs. Tumor suppressor protein TP53 was detected by immunohistochemistry in the nuclei of poorly differentiated, cytokeratin-positive cells of the primary neoplasm and the metastases. Canine oral papillomavirus DNA was not detectable by polymerase chain reaction (PCR).

Alternate JournalJ. Zoo Wildl. Med.