Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.

TitleTranslating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.
Publication TypeJournal Article
Year of Publication2011
AuthorsDolan BP, Bennink JR, Yewdell JW
JournalCellular and molecular life sciences : CMLS
Volume68
Issue9
Pagination1481-9
Date Published2011 May
ISSN1420-9071
KeywordsAntigen Presentation, Endoplasmic Reticulum, Histocompatibility Antigens Class I, Humans, Protein Biosynthesis, Virus Diseases
Abstract

It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of infected cells. Here, we review the evidence for the contribution of DRiPs to antigen processing, pointing to the uncertainties regarding the physical nature of DRiPs, and emphasizing recent findings suggesting that peptide generation is a specialized process involving compartmentalized translation.

DOI10.1007/s00018-011-0656-z
Alternate JournalCell. Mol. Life Sci.