Use of chemotherapy for treatment of a mixed-cell thoracic lymphoma in a horse.

TitleUse of chemotherapy for treatment of a mixed-cell thoracic lymphoma in a horse.
Publication TypeJournal Article
Year of Publication2004
AuthorsSaulez MN, Schlipf JW, Cebra CK, McDonough SP, Bird KE
JournalJournal of the American Veterinary Medical Association
Volume224
Issue5
Pagination733-8, 699
Date Published2004 Mar 1
ISSN0003-1488
KeywordsAnimals, Antineoplastic Combined Chemotherapy Protocols, Cyclophosphamide, Cytarabine, Female, Horse Diseases, Horses, Immunohistochemistry, Lymphoma, Pleural Effusion, Malignant, Prednisolone, Thoracic Neoplasms
Abstract

A 4-year-old Oldenburg mare was evaluated because of signs of lower airway disease and subsequently developed bilateral pleural effusion. Neoplastic cells were not identified in the fluid sample obtained via the initial thoracocentesis. A thoracic mass was detected radiographically, but its location prevented collection of a tissue sample. A diagnosis of lymphoma was made on the basis of results of immunophenotyping of pleural fluid specimens. Treatment of thoracic lymphoma in horses has been attempted, but there are limited data regarding chemotherapeutic-induced remission. In this horse, remission was achieved by use of a chemotherapeutic protocol consisting of administration of cytarabine, cyclophosphamide, and prednisolone. No adverse drug reactions were encountered during treatment. Immunophenotyping of cells in specimens of pleural fluid could be used to determine lymphocyte lineage and may be a useful alternative diagnostic modality when morphologic and cytologic examination of tissue specimens obtained via invasive techniques is not feasible.

Alternate JournalJ. Am. Vet. Med. Assoc.