Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages.

TitleVirulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages.
Publication TypeJournal Article
Year of Publication2010
AuthorsJha SS, Danelishvili L, Wagner D, Maser J, Li Y-jun, Moric I, Vogt S, Yamazaki Y, Lai B, Bermudez LE
JournalBMC microbiology
Volume10
Pagination100
Date Published2010
ISSN1471-2180
KeywordsBacterial Proteins, Cell Line, Gene Expression Profiling, Gene Expression Regulation, Humans, Monocytes, Mycobacterium avium, Vacuoles, Virulence Factors
Abstract

Mycobacterium avium subsp hominissuis (previously Mycobacterium avium subsp avium) is an environmental organism associated with opportunistic infections in humans. Mycobacterium hominissuis infects and replicates within mononuclear phagocytes. Previous study characterized an attenuated mutant in which the PPE gene (MAV_2928) homologous to Rv1787 was inactivated. This mutant, in contrast to the wild-type bacterium, was shown both to have impaired the ability to replicate within macrophages and to have prevented phagosome/lysosome fusion.

DOI10.1111/j.1365-3164.2011.00980.x
Alternate JournalBMC Microbiol.
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