Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.

TitleVitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.
Publication TypeJournal Article
Year of Publication2012
AuthorsFarley SM, Leonard SW, Labut EM, Raines HF, Card DJ, Harrington DJ, Mustacich DJ, Traber MG
JournalMolecular nutrition & food research
Volume56
Issue6
Pagination912-22
Date Published2012 Jun
ISSN1613-4133
Abstract

The mechanism for increased bleeding and decreased vitamin K status accompanying vitamin E supplementation is unknown. We hypothesized that elevated hepatic α-tocopherol (α-T) concentrations may stimulate vitamin K metabolism and excretion. Furthermore, α-T may interfere with the side chain removal of phylloquinone (PK) to form menadione (MN) as an intermediate for synthesis of tissue-specific menaquinone-4 (MK-4).

DOI10.1002/mnfr.201100751
Alternate JournalMol Nutr Food Res