TitleEffective Treatment of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus Species Infections in Macrophages, Biofilm, and Mice by Using Liposomal Ciprofloxacin.
Publication TypeJournal Article
Year of Publication2018
AuthorsBlanchard, JD, Elias, V, Cipolla, D, Gonda, I, Bermudez, LE
JournalAntimicrob Agents Chemother
Volume62
Issue10
Date Published2018 10
ISSN1098-6596
KeywordsAnimals, Biofilms, Female, Humans, Liposomes, Macrophages, Mice, Mice, Inbred C57BL, Microbial Sensitivity Tests, Mycobacterium abscessus, Mycobacterium avium, Polyethylene Glycols
Abstract

Nontuberculous mycobacteria (NTM) affect an increasing number of individuals worldwide. Infection with these organisms is more common in patients with chronic lung conditions, and treatment is challenging. Quinolones, such as ciprofloxacin, have been used to treat patients, but the results have not been encouraging. In this report, we evaluate novel formulations of liposome-encapsulated ciprofloxacin (liposomal ciprofloxacin) and Its efficacy against and was examined in macrophages, in biofilms, and using intranasal instillation mouse models. Liposomal ciprofloxacin was significantly more active than free ciprofloxacin against both pathogens in macrophages and biofilms. When evaluated , treatment with the liposomal ciprofloxacin formulations was associated with significant decreases in the bacterial loads in the lungs of animals infected with and In summary, topical delivery of liposomal ciprofloxacin in the lung at concentrations greater than those achieved in the serum can be effective in the treatment of NTM, and further evaluation is warranted.

DOI10.1128/AAC.00440-18
Alternate JournalAntimicrob. Agents Chemother.
PubMed ID30012773
PubMed Central IDPMC6153787
Grant ListR43 AI106188 / AI / NIAID NIH HHS / United States