TitleElectrophysiological recording from parasitic nematode muscle.
Publication TypeJournal Article
Year of Publication2008
AuthorsRobertson, AP, Puttachary, S, Buxton, SK, Martin, RJ
JournalInvert Neurosci
Date Published2008 Dec
KeywordsAnimals, Electrophysiology, Ion Channels, Microelectrodes, Muscles, Nematoda, Patch-Clamp Techniques

Infection of man and animals with parasitic nematodes is recognized as a significant global problem (McLeod in Int J Parasitol 25(11):1363-1367, 1994; Hotez et al. in N Engl J Med 357(10):1018-1027, 2007). At present control of these infections relies primarily on chemotherapy. There are a limited number of classes of anthelmintic compounds and the majority of these act on ion-channels of the parasite (Martin et al. in Parasitology 113:S137-S156, 1996). In this report, we describe electrophysiological recording techniques as applied to parasitic nematodes. The aim of this report is: (1) to promote the study of ion channels in nematodes to help further the understanding of antinematodal drug action; (2) to describe our recording equipment and experimental protocols; and (3) provide some examples of the information to be gleaned from this approach and how it can increase our understanding of these important pathogens.

Alternate JournalInvert. Neurosci.
PubMed ID19005711
PubMed Central IDPMC2772203
Grant ListR01 AI047194 / AI / NIAID NIH HHS / United States
R01 AI047194-09 / AI / NIAID NIH HHS / United States
R01 AI04719406A1 / AI / NIAID NIH HHS / United States