TitleFatal paraquat poisoning in seven Portland, Oregon, dogs.
Publication TypeJournal Article
Year of Publication2004
AuthorsCope, RB, Bildfell, RJ, Valentine, BA, White, KS, Cooper, BJ, Oncken, A
JournalVeterinary and human toxicology
Volume46
Issue5
Pagination258-64
Date Published2004 Oct
KeywordsRespiratory Insufficiency
Abstract

Paraquat is one of the few broad-spectrum herbicides available in the US; however, it is extremely toxic to companion animals when ingested. Despite its restricted use status, poisoning of dogs and cats remains relatively common. This clinical report documents a series of chronologically and geographically related cases of presumed malicious and fatal sub-acute paraquat poisoning in 7 dogs in Portland, OR. All animals developed acute gastrointestinal disturbance, renal compromise and insidiously progressive respiratory failure. Hyperlipasemia and moderate hypertension were notable featured in 5/7 cases. Trace levels of paraquat were demonstrated in the urine of 4/7 animals by gas-liquid chromatography/mass spectroscopy. Diagnosis in the remaining 3 cases was made through a combination of history or exposure, clinical signs and their progression, and pulmonary and renal histopathology.