TitleThe influence of context on recognition memory in monkeys: effects of hippocampal, parahippocampal and perirhinal lesions.
Publication TypeJournal Article
Year of Publication2015
AuthorsBachevalier, J, Nemanic, S, Alvarado, MC
JournalBehav Brain Res
Volume285
Pagination89-98
Date Published2015 May 15
ISSN1872-7549
KeywordsAnimals, Female, Hippocampus, Ibotenic Acid, Macaca mulatta, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Neurosurgical Procedures, Pattern Recognition, Visual, Photic Stimulation, Recognition (Psychology), Temporal Lobe
Abstract

This study further investigated the specific contributions of the medial temporal lobe structures to contextual recognition memory. Monkeys (Macaca mulatta) with either neurotoxic lesions of the hippocampus, aspiration lesions of the perirhinal cortex and parahippocampal areas TH/TF, or sham operations were tested on five conditions of a visual-paired comparison (VPC) task in which 3-dimensional objects were presented over multicolored backgrounds. In two conditions (Conditions 1 and 2: Context-changes), the sample object was presented on a new background during the retention tests, whereas in the three others (Conditions 3-5: No-context-changes) the sample object was presented over its familiar background. Novelty preference scores of control animals were weaker, but still significantly different from chance, in the Context-changes conditions than on the No-context-changes conditions. Animals in the three experimental groups showed strong preference for novelty on the No-context-change conditions, but weaker novelty preference on the Context-change conditions than controls. Thus, animals in all three lesion types had greater difficulty recognizing an object when its background was different from that used during encoding. The data are consistent with the view that the hippocampal formation, areas TH/TF, and perirhinal cortex contribute interactively to contextual memory processes.

DOI10.1016/j.bbr.2014.07.010
Alternate JournalBehav. Brain Res.
PubMed ID25026097
PubMed Central IDPMC4291303
Grant ListF32 MH010929 / MH / NIMH NIH HHS / United States
F32 MH-10929 / MH / NIMH NIH HHS / United States
P51 OD011132 / OD / NIH HHS / United States
F31 MH-12106 / MH / NIMH NIH HHS / United States
MH-58846 / MH / NIMH NIH HHS / United States
F31 MH012106 / MH / NIMH NIH HHS / United States
R01 MH058846 / MH / NIMH NIH HHS / United States