TitleSingle-channel recording from adult Brugia malayi.
Publication TypeJournal Article
Year of Publication2011
AuthorsRobertson, AP, Puttachary, S, Martin, RJ
JournalInvert Neurosci
Volume11
Issue1
Pagination53-7
Date Published2011 Jun
ISSN1439-1104
KeywordsAnimals, Anthelmintics, Brugia malayi, Female, Humans, Microfilariae, Patch-Clamp Techniques, Receptors, Nicotinic
Abstract

Lymphatic filariasis is a significant cause of morbidity in humans. One of the causative agents is Brugia malayi a clade III nematode. Current therapeutic agents are effective against the microfilaria but less so against the adults residing in the host lymphatics. A large number of anthelmintics act on nematode ion channels including the nicotinic receptors found on nematode somatic muscle. The purpose of this study was to develop a preparation from adult B. malayi that was amenable to patch-clamp recording to facilitate the study of the ion channels present in this organism. We also present a preliminary characterization of the single-channel properties of nicotinic receptors from the adult musculature.

DOI10.1007/s10158-011-0118-1
Alternate JournalInvert. Neurosci.
PubMed ID21590329
Grant ListR 01 A1047194 / / PHS HHS / United States