TitleSingle-channel recording from adult Brugia malayi.
Publication TypeJournal Article
Year of Publication2011
AuthorsRobertson, AP, Puttachary, S, Martin, RJ
JournalInvert Neurosci
Date Published2011 Jun
KeywordsAnimals, Anthelmintics, Brugia malayi, Female, Humans, Microfilariae, Patch-Clamp Techniques, Receptors, Nicotinic

Lymphatic filariasis is a significant cause of morbidity in humans. One of the causative agents is Brugia malayi a clade III nematode. Current therapeutic agents are effective against the microfilaria but less so against the adults residing in the host lymphatics. A large number of anthelmintics act on nematode ion channels including the nicotinic receptors found on nematode somatic muscle. The purpose of this study was to develop a preparation from adult B. malayi that was amenable to patch-clamp recording to facilitate the study of the ion channels present in this organism. We also present a preliminary characterization of the single-channel properties of nicotinic receptors from the adult musculature.

Alternate JournalInvert. Neurosci.
PubMed ID21590329
Grant ListR 01 A1047194 / / PHS HHS / United States