TitleToxicity studies of Calycopteris floribunda Lam. in calf, rabbit and rat.
Publication TypeJournal Article
Year of Publication2006
AuthorsPuttachary, S, Narayana, K, Shridhar, NB, Bhat, A
JournalJ Ethnopharmacol
Volume107
Issue2
Pagination229-33
Date Published2006 Sep 19
ISSN0378-8741
KeywordsAlanine Transaminase, Animals, Blood Glucose, Blood Urea Nitrogen, Cattle, Cholesterol, Combretaceae, Creatinine, Liver, Lung, Male, Pericardium, Plant Extracts, Plant Leaves, Rabbits, Rats, Species Specificity, Toxicity Tests, Acute
Abstract

The toxicological evaluation of the plant Calycopteris floribunda Lam. was done in calf, rabbit and rat. The phytochemical screening revealed the presence of flavonoids, alkaloids, tannins and saponins. Morbidity and mortality was observed in methanol extract-treated rats and rabbits. In rabbits (25 g/kg/day) and calves (35 g/kg/day) fed fresh leaves showed morbidity and mortality with premonitory clinical signs like depression, downer status, polyuria and characteristic forelimb paresis (seen only in rabbits). The serum urea, alanine-amino transferase, glucose and total cholesterol concentrations were significantly (P<0.05) increased compared to control values. Necropsy of calves revealed the congestion of liver, lung and petechiae on epicardium. The present study indicated the toxic nature of the plant in calf, rabbit and rat.

DOI10.1016/j.jep.2006.03.016
Alternate JournalJ Ethnopharmacol
PubMed ID16677787