Link to Lab Website
Medicinal chemistry and synthetic organic chemistry research:
We use chemistry to advance the discovery of new medicines for Neglected Tropical Diseases and bacterial infections. These diseases urgently need safer and more effective treatments. We are currently optimizing a series of compounds with activity against Leishmania parasites, which infect an additional 1.5 million people each year, approximately. However, the amount of research toward new therapies for this disease is minimal. This project was inspired by the anti-Leishmania activity of a known drug. This drug is safely used in post-menopausal women. Unfortunately, the known drug only has modest activity against Leishmania parasites and is expected to have significant side-effects in the broader population. We are researching ways to change the chemical structure to make molecules that are safe for the broad population and more effective against Leishmania parasites.
In general, our research is inspired by natural products, novel compound screening approaches, and re-purposing known drugs as starting points for research. We apply cutting-edge medicinal chemistry research principles often used by the pharmaceutical industry to the discovery of new medicines for infectious diseases that are in urgent need of new therapeutics. The medicinal chemistry approaches we use include Fragment Based Drug Discovery (FBDD), optimization of physiochemical properties, protein crystal Structure Based Drug Design (SBDD), and traditional medicinal chemistry techniques. I tailor the medicinal chemistry approach for the biological target or disease.