Carlson College of Veterinary Medicine

S. Fletcher, Adams, A. M., Johnsen, R. D., Greer, K., Moulton, H. M., and Wilton, S. D., “Dystrophin isoform induction in vivo by antisense-mediated alternative splicing.”, Mol Ther, vol. 18, no. 6, pp. 1218-23, 2010.

H. Yin, Moulton, H. M., Betts, C., Merritt, T., Seow, Y., Ashraf, S., Wang, Q., Boutilier, J., and Wood, M. Ja, “Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.”, Mol Ther, vol. 18, no. 10, pp. 1822-9, 2010.

Q. Wang, Yin, H., Camelliti, P., Betts, C., Moulton, H. M., Lee, H., Saleh, A. F., Gait, M. J., and Wood, M. J. A., “In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy.”, J Gene Med, vol. 12, no. 4, pp. 354-64, 2010.

N. Jearawiriyapaisarn, Moulton, H. M., Sazani, P., Kole, R., and Willis, M. S., “Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers.”, Cardiovasc Res, vol. 85, no. 3, pp. 444-53, 2010.

H. M. Moulton and Moulton, J. D., “Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophy.”, Biochim Biophys Acta, vol. 1798, no. 12, pp. 2296-303, 2010.

H. Yin, Moulton, H. M., Betts, C., and Wood, M., “CPP-directed oligonucleotide exon skipping in animal models of Duchenne muscular dystrophy.”, Methods Mol Biol, vol. 683, pp. 321-38, 2011.

B. W. Neuman, Bederka, L. H., Stein, D. A., Ting, J. P. C., Moulton, H. M., and Buchmeier, M. J., “Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors.”, Antimicrob Agents Chemother, vol. 55, no. 10, pp. 4631-8, 2011.

A. Crisp, Yin, H., Goyenvalle, A., Betts, C., Moulton, H. M., Seow, Y., Babbs, A., Merritt, T., Saleh, A. F., Gait, M. J., Stuckey, D. J., Clarke, K., Davies, K. E., and Wood, M. J. A., “Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.”, Hum Mol Genet, vol. 20, no. 3, pp. 413-21, 2011.

B. Wu, Lu, P., Cloer, C., Shaban, M., Grewal, S., Milazi, S., Shah, S. N., Moulton, H. M., and Lu, Q. Long, “Long-term rescue of dystrophin expression and improvement in muscle pathology and function in dystrophic mdx mice by peptide-conjugated morpholino.”, Am J Pathol, vol. 181, no. 2, pp. 392-400, 2012.

M. Nizzardo, Simone, C., Salani, S., Ruepp, M. - D., Rizzo, F., Ruggieri, M., Zanetta, C., Brajkovic, S., Moulton, H. M., Müehlemann, O., Bresolin, N., Comi, G. P., and Corti, S., “Effect of combined systemic and local morpholino treatment on the spinal muscular atrophy Δ7 mouse model phenotype.”, Clin Ther, vol. 36, no. 3, pp. 340-56.e5, 2014.

B. Wu, Cloer, C., Lu, P., Milazi, S., Shaban, M., Shah, S. N., Marston-Poe, L., Moulton, H. M., and Lu, Q. L., “Exon skipping restores dystrophin expression, but fails to prevent disease progression in later stage dystrophic dko mice.”, Gene Ther, vol. 21, no. 9, pp. 785-93, 2014.

R. Rajsbaum, Versteeg, G. A., Schmid, S., Maestre, A. M., Belicha-Villanueva, A., Martínez-Romero, C., Patel, J. R., Morrison, J., Pisanelli, G., Miorin, L., Laurent-Rolle, M., Moulton, H. M., Stein, D. A., Fernandez-Sesma, A., tenOever, B. R., and García-Sastre, A., “Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.”, Immunity, vol. 40, no. 6, pp. 880-95, 2014.

L. Louis Seifert, Si, C., Saha, D., Sadic, M., de Vries, M., Ballentine, S., Briley, A., Wang, G., Valero-Jimenez, A. M., Mohamed, A., Schaefer, U., Moulton, H. M., García-Sastre, A., Tripathi, S., Rosenberg, B. R., and Dittmann, M., “The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response.”, PLoS Pathog, vol. 15, no. 11, p. e1007634, 2019.

H. Limburg, Harbig, A., Bestle, D., Stein, D. A., Moulton, H. M., Jaeger, J., Janga, H., Hardes, K., Koepke, J., Schulte, L., Koczulla, A. Rembert, Schmeck, B., Klenk, H. - D., and Böttcher-Friebertshäuser, E., “TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes.”, J Virol, vol. 93, no. 21, 2019.

Y. Dang, van Heusden, C., Nickerson, V., Chung, F., Wang, Y., Quinney, N. L., Gentzsch, M., Randell, S. H., Moulton, H. M., Kole, R., Ni, A., Juliano, R. L., and Kreda, S. M., “Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung.”, Nucleic Acids Res, vol. 49, no. 11, pp. 6100-6113, 2021.

D. Bestle, Limburg, H., Kruhl, D., Harbig, A., Stein, D. A., Moulton, H. M., Matrosovich, M., Abdelwhab, E. M., Stech, J., and Böttcher-Friebertshäuser, E., “Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells.”, J Virol, vol. 95, no. 20, p. e0090621, 2021.