Carlson College of Veterinary Medicine

J. L. Sanders, Zhou, Y., Moulton, H. M., Moulton, Z. X., McLeod, R., Dubey, J. P., Weiss, L. M., and Kent, M. L., “The zebrafish, Danio rerio, as a model for Toxoplasma gondii: an initial description of infection in fish.”, J Fish Dis, vol. 38, no. 7, pp. 675-9, 2015.

R. Rajsbaum, Versteeg, G. A., Schmid, S., Maestre, A. M., Belicha-Villanueva, A., Martínez-Romero, C., Patel, J. R., Morrison, J., Pisanelli, G., Miorin, L., Laurent-Rolle, M., Moulton, H. M., Stein, D. A., Fernandez-Sesma, A., tenOever, B. R., and García-Sastre, A., “Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.”, Immunity, vol. 40, no. 6, pp. 880-95, 2014.

H. Limburg, Harbig, A., Bestle, D., Stein, D. A., Moulton, H. M., Jaeger, J., Janga, H., Hardes, K., Koepke, J., Schulte, L., Koczulla, A. Rembert, Schmeck, B., Klenk, H. - D., and Böttcher-Friebertshäuser, E., “TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes.”, J Virol, vol. 93, no. 21, 2019.

D. Bestle, Heindl, M. Ruth, Limburg, H., van, T. Van Lam, Pilgram, O., Moulton, H. M., Stein, D. A., Hardes, K., Eickmann, M., Dolnik, O., Rohde, C., Klenk, H. - D., Garten, W., Steinmetzer, T., and Böttcher-Friebertshäuser, E., “TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.”, Life Sci Alliance, vol. 3, no. 9, 2020.

J. Boutilier and Moulton, H. M., “Surface Plasmon Resonance-Based Concentration Determination Assay: Label-Free and Antibody-Free Quantification of Morpholinos.”, Methods Mol Biol, vol. 1565, pp. 251-263, 2017.

J. Kim, Clark, K., Barton, C., Tanguay, R., and Moulton, H. M., “A Novel Zebrafish Model for Assessing In Vivo Delivery of Morpholino Oligomers.”, Methods Mol Biol, vol. 1828, pp. 293-306, 2018.

H. M. Moulton and Moulton, J. D., “Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophy.”, Biochim Biophys Acta, vol. 1798, no. 12, pp. 2296-303, 2010.

S. Tripathi, Pohl, M. O., Zhou, Y., Rodriguez-Frandsen, A., Wang, G., Stein, D. A., Moulton, H. M., DeJesus, P., Che, J., Mulder, L. C. F., Yángüez, E., Andenmatten, D., Pache, L., Manicassamy, B., Albrecht, R. A., Gonzalez, M. G., Nguyen, Q., Brass, A., Elledge, S., White, M., Shapira, S., Hacohen, N., Karlas, A., Meyer, T. F., Shales, M., Gatorano, A., Johnson, J. R., Jang, G., Johnson, T., Verschueren, E., Sanders, D., Krogan, N., Shaw, M., König, R., Stertz, S., García-Sastre, A., and Chanda, S. K., “Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.”, Cell Host Microbe, vol. 18, no. 6, pp. 723-35, 2015.

B. Wu, Lu, P., Cloer, C., Shaban, M., Grewal, S., Milazi, S., Shah, S. N., Moulton, H. M., and Lu, Q. Long, “Long-term rescue of dystrophin expression and improvement in muscle pathology and function in dystrophic mdx mice by peptide-conjugated morpholino.”, Am J Pathol, vol. 181, no. 2, pp. 392-400, 2012.

N. Jearawiriyapaisarn, Moulton, H. M., Sazani, P., Kole, R., and Willis, M. S., “Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers.”, Cardiovasc Res, vol. 85, no. 3, pp. 444-53, 2010.

K. Rosenke, Leventhal, S., Moulton, H. M., Hatlevig, S., Hawman, D., Feldmann, H., and Stein, D. A., “Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers.”, J Antimicrob Chemother, vol. 76, no. 2, pp. 413-417, 2021.

H. M. Moulton, “In vivo delivery of morpholino oligos by cell-penetrating peptides.”, Curr Pharm Des, vol. 19, no. 16, pp. 2963-9, 2013.

Q. Wang, Yin, H., Camelliti, P., Betts, C., Moulton, H. M., Lee, H., Saleh, A. F., Gait, M. J., and Wood, M. J. A., “In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy.”, J Gene Med, vol. 12, no. 4, pp. 354-64, 2010.

D. Bestle, Limburg, H., Kruhl, D., Harbig, A., Stein, D. A., Moulton, H. M., Matrosovich, M., Abdelwhab, E. M., Stech, J., and Böttcher-Friebertshäuser, E., “Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells.”, J Virol, vol. 95, no. 20, p. e0090621, 2021.

H. Yin, Moulton, H. M., Betts, C., Merritt, T., Seow, Y., Ashraf, S., Wang, Q., Boutilier, J., and Wood, M. Ja, “Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.”, Mol Ther, vol. 18, no. 10, pp. 1822-9, 2010.

Y. Echigoya, Trieu, N., Duddy, W., Moulton, H. M., Yin, H., Partridge, T. A., Hoffman, E. P., Kornegay, J. N., Rohret, F. A., Rogers, C. S., and Yokota, T., “A Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping.”, Int J Mol Sci, vol. 22, no. 23, 2021.

B. Wu, Cloer, C., Lu, P., Milazi, S., Shaban, M., Shah, S. N., Marston-Poe, L., Moulton, H. M., and Lu, Q. L., “Exon skipping restores dystrophin expression, but fails to prevent disease progression in later stage dystrophic dko mice.”, Gene Ther, vol. 21, no. 9, pp. 785-93, 2014.

L. Louis Seifert, Si, C., Saha, D., Sadic, M., de Vries, M., Ballentine, S., Briley, A., Wang, G., Valero-Jimenez, A. M., Mohamed, A., Schaefer, U., Moulton, H. M., García-Sastre, A., Tripathi, S., Rosenberg, B. R., and Dittmann, M., “The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response.”, PLoS Pathog, vol. 15, no. 11, p. e1007634, 2019.

Y. Dang, van Heusden, C., Nickerson, V., Chung, F., Wang, Y., Quinney, N. L., Gentzsch, M., Randell, S. H., Moulton, H. M., Kole, R., Ni, A., Juliano, R. L., and Kreda, S. M., “Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung.”, Nucleic Acids Res, vol. 49, no. 11, pp. 6100-6113, 2021.

Y. Echigoya, Nakamura, A., Nagata, T., Urasawa, N., Lim, K. Rowel Q., Trieu, N., Panesar, D., Kuraoka, M., Moulton, H. M., Saito, T., Aoki, Y., Iversen, P., Sazani, P., Kole, R., Maruyama, R., Partridge, T., Takeda, S. 'ichi, and Yokota, T., “Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy.”, Proc Natl Acad Sci U S A, vol. 114, no. 16, pp. 4213-4218, 2017.

X. Gao, Zhao, J., Han, G., Zhang, Y., Dong, X., Cao, L., Wang, Q., Moulton, H. M., and Yin, H., “Effective dystrophin restoration by a novel muscle-homing peptide-morpholino conjugate in dystrophin-deficient mdx mice.”, Mol Ther, vol. 22, no. 7, pp. 1333-1341, 2014.

M. Nizzardo, Simone, C., Salani, S., Ruepp, M. - D., Rizzo, F., Ruggieri, M., Zanetta, C., Brajkovic, S., Moulton, H. M., Müehlemann, O., Bresolin, N., Comi, G. P., and Corti, S., “Effect of combined systemic and local morpholino treatment on the spinal muscular atrophy Δ7 mouse model phenotype.”, Clin Ther, vol. 36, no. 3, pp. 340-56.e5, 2014.

S. Fletcher, Adams, A. M., Johnsen, R. D., Greer, K., Moulton, H. M., and Wilton, S. D., “Dystrophin isoform induction in vivo by antisense-mediated alternative splicing.”, Mol Ther, vol. 18, no. 6, pp. 1218-23, 2010.

A. Crisp, Yin, H., Goyenvalle, A., Betts, C., Moulton, H. M., Seow, Y., Babbs, A., Merritt, T., Saleh, A. F., Gait, M. J., Stuckey, D. J., Clarke, K., Davies, K. E., and Wood, M. J. A., “Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.”, Hum Mol Genet, vol. 20, no. 3, pp. 413-21, 2011.

B. W. Neuman, Bederka, L. H., Stein, D. A., Ting, J. P. C., Moulton, H. M., and Buchmeier, M. J., “Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors.”, Antimicrob Agents Chemother, vol. 55, no. 10, pp. 4631-8, 2011.