Found 55 results
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Journal Article
B. Wu, Moulton, H. M., Iversen, P. L., Jiang, J., Li, J., Li, J., Spurney, C. F., Sali, A., Guerron, A. D., Nagaraju, K., Doran, T., Lu, P., Xiao, X., and Lu, Q. Long, Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer., Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 39, pp. 14814-9, 2008.
B. Wu, Cloer, C., Lu, P., Milazi, S., Shaban, M., Shah, S. N., Marston-Poe, L., Moulton, H. M., and Lu, Q. L., Exon skipping restores dystrophin expression, but fails to prevent disease progression in later stage dystrophic dko mice., Gene therapy, vol. 21, no. 9, pp. 785-93, 2014.
H. Yin, Moulton, H. M., Betts, C., Merritt, T., Seow, Y., Ashraf, S., Wang, Q., Boutilier, J., and Wood, M. J. A., Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO., Molecular therapy : the journal of the American Society of Gene Therapy, vol. 18, no. 10, pp. 1822-9, 2010.
H. Yin, Moulton, H. M., Betts, C., Seow, Y., Boutilier, J., Iverson, P. L., and Wood, M. J. A., A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice., Human molecular genetics, vol. 18, no. 22, pp. 4405-14, 2009.
H. M. Moulton, Hase, M. C., Smith, K. M., and Iversen, P. L., HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers., Antisense & nucleic acid drug development, vol. 13, no. 1, pp. 31-43, 2003.
Q. Wang, Yin, H., Camelliti, P., Betts, C., Moulton, H. M., Lee, H., Saleh, A. F., Gait, M. J., and Wood, M. J. A., In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy., The journal of gene medicine, vol. 12, no. 4, pp. 354-64, 2010.
H. M. Moulton, In vivo delivery of morpholino oligos by cell-penetrating peptides., Current pharmaceutical design, vol. 19, no. 16, pp. 2963-9, 2013.
G. McClorey, Fall, A. M., Moulton, H. M., Iversen, P. L., Rasko, J. E., Ryan, M., Fletcher, S., and Wilton, S. D., Induced dystrophin exon skipping in human muscle explants., Neuromuscular disorders : NMD, vol. 16, no. 9-10, pp. 583-90, 2006.
B. W. Neuman, Stein, D. A., Kroeker, A. D., Moulton, H. M., Bestwick, R. K., Iversen, P. L., and Buchmeier, M. J., Inhibition and escape of SARS-CoV treated with antisense morpholino oligomers., Advances in experimental medicine and biology, vol. 581, pp. 567-71, 2006.
B. W. Neuman, Stein, D. A., Kroeker, A. D., Churchill, M. J., Kim, A. M., Kuhn, P., Dawson, P., Moulton, H. M., Bestwick, R. K., Iversen, P. L., and Buchmeier, M. J., Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers., Journal of virology, vol. 79, no. 15, pp. 9665-76, 2005.
J. Yuan, Stein, D. A., Lim, T., Qiu, D., Coughlin, S., Liu, Z., Wang, Y., Blouch, R., Moulton, H. M., Iversen, P. L., and Yang, D., Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site., Journal of virology, vol. 80, no. 23, pp. 11510-9, 2006.
T. S. Deas, Binduga-Gajewska, I., Tilgner, M., Ren, P., Stein, D. A., Moulton, H. M., Iversen, P. L., Kauffman, E. B., Kramer, L. D., and Shi, P. Y., Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication., J Virol, vol. 79, no. 8, pp. 4599-609, 2005.
B. L. Geller, Deere, J. D., Stein, D. A., Kroeker, A. D., Moulton, H. M., and Iversen, P. L., Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers., Antimicrobial agents and chemotherapy, vol. 47, no. 10, pp. 3233-9, 2003.
M. Alonso, Stein, D. A., Thomann, E., Moulton, H. M., Leong, J. C., Iversen, P., and Mourich, D. V., Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide-conjugated morpholino oligomers., Journal of fish diseases, vol. 28, no. 7, pp. 399-410, 2005.
Y. - J. Zhang, Wang, K. - Y., Stein, D. A., Patel, D., Watkins, R., Moulton, H. M., Iversen, P. L., and Matson, D. O., Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers., Antiviral research, vol. 73, no. 1, pp. 12-23, 2007.
N. Jearawiriyapaisarn, Moulton, H. M., Sazani, P., Kole, R., and Willis, M. S., Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers., Cardiovascular research, vol. 85, no. 3, pp. 444-53, 2010.
B. Wu, Lu, P., Cloer, C., Shaban, M., Grewal, S., Milazi, S., Shah, S. N., Moulton, H. M., and Lu, Q. Long, Long-term rescue of dystrophin expression and improvement in muscle pathology and function in dystrophic mdx mice by peptide-conjugated morpholino., The American journal of pathology, vol. 181, no. 2, pp. 392-400, 2012.
P. L. Iversen, Mourich, D. V., and Moulton, H. M., Monoclonal antibodies to two epitopes of beta-human chorionic gonadotropin for the treatment of cancer., Current opinion in molecular therapeutics, vol. 5, no. 2, pp. 156-60, 2003.
S. Fletcher, Honeyman, K., Fall, A. M., Harding, P. L., Johnsen, R. D., Steinhaus, J. P., Moulton, H. M., Iversen, P. L., and Wilton, S. D., Morpholino oligomer-mediated exon skipping averts the onset of dystrophic pathology in the mdx mouse., Molecular therapy : the journal of the American Society of Gene Therapy, vol. 15, no. 9, pp. 1587-92, 2007.
H. M. Moulton and Moulton, J. D., Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophy., Biochimica et biophysica acta, vol. 1798, no. 12, pp. 2296-303, 2010.
H. M. Moulton and Moulton, J. D., Peptide-assisted delivery of steric-blocking antisense oligomers., Current opinion in molecular therapeutics, vol. 5, no. 2, pp. 123-32, 2003.
S. Abes, Moulton, H. M., Turner, J., Clair, P., Richard, J. P., Iversen, P., Gait, M. J., and Lebleu, B., Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides., Biochemical Society transactions, vol. 35, no. Pt 1, pp. 53-5, 2007.
H. M. Moulton, Wu, B., Jearawiriyapaisarn, N., Sazani, P., Lu, Q. Long, and Kole, R., Peptide-morpholino conjugate: a promising therapeutic for Duchenne muscular dystrophy., Annals of the New York Academy of Sciences, vol. 1175, pp. 55-60, 2009.
A. Amantana, Moulton, H. M., Cate, M. L., Reddy, M. T., Whitehead, T., Hassinger, J. N., Youngblood, D. S., and Iversen, P. L., Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate., Bioconjugate chemistry, vol. 18, no. 4, pp. 1325-31, 2007.
S. Svasti, Suwanmanee, T., Fucharoen, S., Moulton, H. M., Nelson, M. H., Maeda, N., Smithies, O., and Kole, R., RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice., Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 4, pp. 1205-10, 2009.

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