Found 55 results
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Journal Article
H. M. Moulton, Hase, M. C., Smith, K. M., and Iversen, P. L., HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers., Antisense & nucleic acid drug development, vol. 13, no. 1, pp. 31-43, 2003.
H. Yin, Moulton, H. M., Betts, C., Seow, Y., Boutilier, J., Iverson, P. L., and Wood, M. J. A., A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice., Human molecular genetics, vol. 18, no. 22, pp. 4405-14, 2009.
H. Yin, Moulton, H. M., Betts, C., Merritt, T., Seow, Y., Ashraf, S., Wang, Q., Boutilier, J., and Wood, M. J. A., Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO., Molecular therapy : the journal of the American Society of Gene Therapy, vol. 18, no. 10, pp. 1822-9, 2010.
B. Wu, Cloer, C., Lu, P., Milazi, S., Shaban, M., Shah, S. N., Marston-Poe, L., Moulton, H. M., and Lu, Q. L., Exon skipping restores dystrophin expression, but fails to prevent disease progression in later stage dystrophic dko mice., Gene therapy, vol. 21, no. 9, pp. 785-93, 2014.
B. Wu, Moulton, H. M., Iversen, P. L., Jiang, J., Li, J., Li, J., Spurney, C. F., Sali, A., Guerron, A. D., Nagaraju, K., Doran, T., Lu, P., Xiao, X., and Lu, Q. Long, Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer., Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 39, pp. 14814-9, 2008.
X. Gao, Zhao, J., Han, G., Zhang, Y., Dong, X., Cao, L., Wang, Q., Moulton, H. M., and Yin, H., Effective dystrophin restoration by a novel muscle-homing peptide-morpholino conjugate in dystrophin-deficient mdx mice., Molecular therapy : the journal of the American Society of Gene Therapy, vol. 22, no. 7, pp. 1333-41, 2014.
M. Nizzardo, Simone, C., Salani, S., Ruepp, M. - D., Rizzo, F., Ruggieri, M., Zanetta, C., Brajkovic, S., Moulton, H. M., Müehlemann, O., Bresolin, N., Comi, G. P., and Corti, S., Effect of combined systemic and local morpholino treatment on the spinal muscular atrophy Δ7 mouse model phenotype., Clinical therapeutics, vol. 36, no. 3, pp. 340-56.e5, 2014.
S. Fletcher, Adams, A. M., Johnsen, R. D., Greer, K., Moulton, H. M., and Wilton, S. D., Dystrophin isoform induction in vivo by antisense-mediated alternative splicing., Molecular therapy : the journal of the American Society of Gene Therapy, vol. 18, no. 6, pp. 1218-23, 2010.
A. Crisp, Yin, H., Goyenvalle, A., Betts, C., Moulton, H. M., Seow, Y., Babbs, A., Merritt, T., Saleh, A. F., Gait, M. J., Stuckey, D. J., Clarke, K., Davies, K. E., and Wood, M. J. A., Diaphragm rescue alone prevents heart dysfunction in dystrophic mice., Human molecular genetics, vol. 20, no. 3, pp. 413-21, 2011.
B. W. Neuman, Bederka, L. H., Stein, D. A., Ting, J. P. C., Moulton, H. M., and Buchmeier, M. J., Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors., Antimicrobial agents and chemotherapy, vol. 55, no. 10, pp. 4631-8, 2011.
R. Abes, Moulton, H. M., Clair, P., Yang, S. - T., Abes, S., Melikov, K., Prevot, P., Youngblood, D. S., Iversen, P. L., Chernomordik, L. V., and Lebleu, B., Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies., Nucleic acids research, vol. 36, no. 20, pp. 6343-54, 2008.
H. Yin, Moulton, H. M., Betts, C., and Wood, M., CPP-directed oligonucleotide exon skipping in animal models of Duchenne muscular dystrophy., Methods in molecular biology (Clifton, N.J.), vol. 683, pp. 321-38, 2011.
H. Yin, Boisguerin, P., Moulton, H. M., Betts, C., Seow, Y., Boutilier, J., Wang, Q., Walsh, A., Lebleu, B., and Wood, M. J. A., Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency., Molecular therapy. Nucleic acids, vol. 2, p. e124, 2013.
F. Debart, Abes, S., Deglane, G., Moulton, H. M., Clair, P., Gait, M. J., Vasseur, J. - J., and Lebleu, B., Chemical modifications to improve the cellular uptake of oligonucleotides., Current topics in medicinal chemistry, vol. 7, no. 7, pp. 727-37, 2007.
D. L. Swenson, Warfield, K. L., Warren, T. K., Lovejoy, C., Hassinger, J. N., Ruthel, G., Blouch, R. E., Moulton, H. M., Weller, D. D., Iversen, P. L., and Bavari, S., Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection., Antimicrobial agents and chemotherapy, vol. 53, no. 5, pp. 2089-99, 2009.
H. M. Moulton, Nelson, M. H., Hatlevig, S. A., Reddy, M. T., and Iversen, P. L., Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides., Bioconjugate chemistry, vol. 15, no. 2, pp. 290-9, 2004.
R. Abes, Arzumanov, A. A., Moulton, H. M., Abes, S., Ivanova, G. D., Iversen, P. L., Gait, M. J., and Lebleu, B., Cell-penetrating-peptide-based delivery of oligonucleotides: an overview., Biochemical Society transactions, vol. 35, no. Pt 4, pp. 775-9, 2007.
H. M. Moulton, Cell-penetrating peptides enhance systemic delivery of antisense morpholino oligomers., Methods in molecular biology (Clifton, N.J.), vol. 867, pp. 407-14, 2012.
R. P. Wu, Youngblood, D. S., Hassinger, J. N., Lovejoy, C. E., Nelson, M. H., Iversen, P. L., and Moulton, H. M., Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity., Nucleic acids research, vol. 35, no. 15, pp. 5182-91, 2007.
H. M. Moulton, Fletcher, S., Neuman, B. W., McClorey, G., Stein, D. A., Abes, S., Wilton, S. D., Buchmeier, M. J., Lebleu, B., and Iversen, P. L., Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo., Biochemical Society transactions, vol. 35, no. Pt 4, pp. 826-8, 2007.
H. Yin, Moulton, H. M., Seow, Y., Boyd, C., Boutilier, J., Iverson, P., and Wood, M. J. A., Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function., Human molecular genetics, vol. 17, no. 24, pp. 3909-18, 2008.
B. Lebleu, Moulton, H. M., Abes, R., Ivanova, G. D., Abes, S., Stein, D. A., Iversen, P. L., Arzumanov, A. A., and Gait, M. J., Cell penetrating peptide conjugates of steric block oligonucleotides., Advanced drug delivery reviews, vol. 60, no. 4-5, pp. 517-29, 2008.
M. H. Nelson, Stein, D. A., Kroeker, A. D., Hatlevig, S. A., Iversen, P. L., and Moulton, H. M., Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificity., Bioconjugate chemistry, vol. 16, no. 4, pp. 959-66, 2005.
H. M. Moulton and Moulton, J. D., Arginine-rich cell-penetrating peptides with uncharged antisense oligomers., Drug discovery today, vol. 9, no. 20, p. 870, 2004.
N. B. Marshall, Oda, S. K., London, C. A., Moulton, H. M., Iversen, P. L., Kerkvliet, N. I., and Mourich, D. V., Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing., Journal of immunological methods, vol. 325, no. 1-2, pp. 114-26, 2007.

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