Found 55 results
Author Title [ Type(Desc)] Year
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Journal Article
H. M. Moulton, Yoshihara, P. H., Mason, D. H., Iversen, P. L., and Triozzi, P. L., “Active specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survival.”, Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 8, no. 7, pp. 2044-51, 2002.
B. W. Neuman, Stein, D. A., Kroeker, A. D., Paulino, A. D., Moulton, H. M., Iversen, P. L., and Buchmeier, M. J., “Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growth.”, Journal of virology, vol. 78, no. 11, pp. 5891-9, 2004.
G. McClorey, Moulton, H. M., Iversen, P. L., Fletcher, S., and Wilton, S. D., “Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD.”, Gene therapy, vol. 13, no. 19, pp. 1373-81, 2006.
R. Burrer, Neuman, B. W., Ting, J. P. C., Stein, D. A., Moulton, H. M., Iversen, P. L., Kuhn, P., and Buchmeier, M. J., “Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models.”, Journal of virology, vol. 81, no. 11, pp. 5637-48, 2007.
R. Abes, Arzumanov, A., Moulton, H. M., Abes, S., Ivanova, G., Gait, M. J., Iversen, P., and Lebleu, B., “Arginine-rich cell penetrating peptides: design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides.”, Journal of peptide science : an official publication of the European Peptide Society, vol. 14, no. 4, pp. 455-60, 2008.
N. B. Marshall, Oda, S. K., London, C. A., Moulton, H. M., Iversen, P. L., Kerkvliet, N. I., and Mourich, D. V., “Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing.”, Journal of immunological methods, vol. 325, no. 1-2, pp. 114-26, 2007.
H. M. Moulton and Moulton, J. D., “Arginine-rich cell-penetrating peptides with uncharged antisense oligomers.”, Drug discovery today, vol. 9, no. 20, p. 870, 2004.
M. H. Nelson, Stein, D. A., Kroeker, A. D., Hatlevig, S. A., Iversen, P. L., and Moulton, H. M., “Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificity.”, Bioconjugate chemistry, vol. 16, no. 4, pp. 959-66, 2005.
B. Lebleu, Moulton, H. M., Abes, R., Ivanova, G. D., Abes, S., Stein, D. A., Iversen, P. L., Arzumanov, A. A., and Gait, M. J., “Cell penetrating peptide conjugates of steric block oligonucleotides.”, Advanced drug delivery reviews, vol. 60, no. 4-5, pp. 517-29, 2008.
H. Yin, Moulton, H. M., Seow, Y., Boyd, C., Boutilier, J., Iverson, P., and Wood, M. J. A., “Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function.”, Human molecular genetics, vol. 17, no. 24, pp. 3909-18, 2008.
H. M. Moulton, Fletcher, S., Neuman, B. W., McClorey, G., Stein, D. A., Abes, S., Wilton, S. D., Buchmeier, M. J., Lebleu, B., and Iversen, P. L., “Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo.”, Biochemical Society transactions, vol. 35, no. Pt 4, pp. 826-8, 2007.
R. P. Wu, Youngblood, D. S., Hassinger, J. N., Lovejoy, C. E., Nelson, M. H., Iversen, P. L., and Moulton, H. M., “Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity.”, Nucleic acids research, vol. 35, no. 15, pp. 5182-91, 2007.
H. M. Moulton, “Cell-penetrating peptides enhance systemic delivery of antisense morpholino oligomers.”, Methods in molecular biology (Clifton, N.J.), vol. 867, pp. 407-14, 2012.
R. Abes, Arzumanov, A. A., Moulton, H. M., Abes, S., Ivanova, G. D., Iversen, P. L., Gait, M. J., and Lebleu, B., “Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.”, Biochemical Society transactions, vol. 35, no. Pt 4, pp. 775-9, 2007.
H. M. Moulton, Nelson, M. H., Hatlevig, S. A., Reddy, M. T., and Iversen, P. L., “Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.”, Bioconjugate chemistry, vol. 15, no. 2, pp. 290-9, 2004.
D. L. Swenson, Warfield, K. L., Warren, T. K., Lovejoy, C., Hassinger, J. N., Ruthel, G., Blouch, R. E., Moulton, H. M., Weller, D. D., Iversen, P. L., and Bavari, S., “Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.”, Antimicrobial agents and chemotherapy, vol. 53, no. 5, pp. 2089-99, 2009.
F. Debart, Abes, S., Deglane, G., Moulton, H. M., Clair, P., Gait, M. J., Vasseur, J. - J., and Lebleu, B., “Chemical modifications to improve the cellular uptake of oligonucleotides.”, Current topics in medicinal chemistry, vol. 7, no. 7, pp. 727-37, 2007.
H. Yin, Boisguerin, P., Moulton, H. M., Betts, C., Seow, Y., Boutilier, J., Wang, Q., Walsh, A., Lebleu, B., and Wood, M. J. A., “Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency.”, Molecular therapy. Nucleic acids, vol. 2, p. e124, 2013.
H. Yin, Moulton, H. M., Betts, C., and Wood, M., “CPP-directed oligonucleotide exon skipping in animal models of Duchenne muscular dystrophy.”, Methods in molecular biology (Clifton, N.J.), vol. 683, pp. 321-38, 2011.
R. Abes, Moulton, H. M., Clair, P., Yang, S. - T., Abes, S., Melikov, K., Prevot, P., Youngblood, D. S., Iversen, P. L., Chernomordik, L. V., and Lebleu, B., “Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies.”, Nucleic acids research, vol. 36, no. 20, pp. 6343-54, 2008.
B. W. Neuman, Bederka, L. H., Stein, D. A., Ting, J. P. C., Moulton, H. M., and Buchmeier, M. J., “Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors.”, Antimicrobial agents and chemotherapy, vol. 55, no. 10, pp. 4631-8, 2011.
A. Crisp, Yin, H., Goyenvalle, A., Betts, C., Moulton, H. M., Seow, Y., Babbs, A., Merritt, T., Saleh, A. F., Gait, M. J., Stuckey, D. J., Clarke, K., Davies, K. E., and Wood, M. J. A., “Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.”, Human molecular genetics, vol. 20, no. 3, pp. 413-21, 2011.
S. Fletcher, Adams, A. M., Johnsen, R. D., Greer, K., Moulton, H. M., and Wilton, S. D., “Dystrophin isoform induction in vivo by antisense-mediated alternative splicing.”, Molecular therapy : the journal of the American Society of Gene Therapy, vol. 18, no. 6, pp. 1218-23, 2010.
M. Nizzardo, Simone, C., Salani, S., Ruepp, M. - D., Rizzo, F., Ruggieri, M., Zanetta, C., Brajkovic, S., Moulton, H. M., Müehlemann, O., Bresolin, N., Comi, G. P., and Corti, S., “Effect of combined systemic and local morpholino treatment on the spinal muscular atrophy Δ7 mouse model phenotype.”, Clinical therapeutics, vol. 36, no. 3, pp. 340-56.e5, 2014.
X. Gao, Zhao, J., Han, G., Zhang, Y., Dong, X., Cao, L., Wang, Q., Moulton, H. M., and Yin, H., “Effective dystrophin restoration by a novel muscle-homing peptide-morpholino conjugate in dystrophin-deficient mdx mice.”, Molecular therapy : the journal of the American Society of Gene Therapy, vol. 22, no. 7, pp. 1333-41, 2014.

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