Found 100 results
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2021
M. Bersani, Rizzuti, M., Pagliari, E., Garbellini, M., Saccomanno, D., Moulton, H. M., Bresolin, N., Comi, G. P., Corti, S., and Nizzardo, M., “Cell-penetrating peptide-conjugated Morpholino rescues SMA in a symptomatic preclinical model.”, Mol Ther, 2021.
G. Green, Johnson, S. M., Costello, H., Brakel, K., Harder, O., Oomens, A. G., Peeples, M. E., Moulton, H. M., and Niewiesk, S., “CX3CR1 Is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats.”, J Virol, vol. 95, no. 16, p. e0001021, 2021.
Y. Dang, van Heusden, C., Nickerson, V., Chung, F., Wang, Y., Quinney, N. L., Gentzsch, M., Randell, S. H., Moulton, H. M., Kole, R., Ni, A., Juliano, R. L., and Kreda, S. M., “Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung.”, Nucleic Acids Res, vol. 49, no. 11, pp. 6100-6113, 2021.
Y. Echigoya, Trieu, N., Duddy, W., Moulton, H. M., Yin, H., Partridge, T. A., Hoffman, E. P., Kornegay, J. N., Rohret, F. A., Rogers, C. S., and Yokota, T., “A Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping.”, Int J Mol Sci, vol. 22, no. 23, 2021.
D. Bestle, Limburg, H., Kruhl, D., Harbig, A., Stein, D. A., Moulton, H. M., Matrosovich, M., Abdelwhab, E. M., Stech, J., and Böttcher-Friebertshäuser, E., “Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells.”, J Virol, vol. 95, no. 20, p. e0090621, 2021.
K. Rosenke, Leventhal, S., Moulton, H. M., Hatlevig, S., Hawman, D., Feldmann, H., and Stein, D. A., “Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers.”, J Antimicrob Chemother, vol. 76, no. 2, pp. 413-417, 2021.
N. Ran, Lin, C., Leng, L., Han, G., Geng, M., Wu, Y., Bittner, S., Moulton, H. M., and Yin, H., “MOTS-c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice.”, EMBO Mol Med, vol. 13, no. 2, p. e12993, 2021.
L. Martin-Sancho, Tripathi, S., Rodriguez-Frandsen, A., Pache, L., Sanchez-Aparicio, M., McGregor, M. J., Haas, K. M., Swaney, D. L., Nguyen, T. T., Mamede, J. I., Churas, C., Pratt, D., Rosenthal, S. B., Riva, L., Nguyen, C., Beltran-Raygoza, N., Soonthornvacharin, S., Wang, G., Jimenez-Morales, D., De Jesus, P. D., Moulton, H. M., Stein, D. A., Chang, M. W., Benner, C., Ideker, T., Albrecht, R. A., Hultquist, J. F., Krogan, N. J., García-Sastre, A., and Chanda, S. K., “Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy.”, Nat Microbiol, vol. 6, no. 10, pp. 1319-1333, 2021.
2020
M. McPhillie, Zhou, Y., Bissati, K. El, Dubey, J., Lorenzi, H., Capper, M., Lukens, A. K., Hickman, M., Muench, S., Verma, S. Kumar, Weber, C. R., Wheeler, K., Gordon, J., Sanders, J., Moulton, H. M., Wang, K., Kim, T. - K., He, Y., Santos, T., Woods, S., Lee, P., Donkin, D., Kim, E., Fraczek, L., Lykins, J., Esaa, F., Alibana-Clouser, F., Dovgin, S., Weiss, L., Brasseur, G., Wirth, D., Kent, M. L., Hood, L., Meunieur, B., Roberts, C. W., S Hasnain, S., Antonyuk, S. V., Fishwick, C., and McLeod, R., “Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.”, Sci Rep, vol. 10, no. 1, p. 5512, 2020.
H. Yin, Boisguerin, P., Moulton, H. M., Betts, C., Seow, Y., Boutilier, J., Wang, Q., Walsh, A., Lebleu, B., and Wood, M. J. A., “Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency.”, Mol Ther Nucleic Acids, vol. 22, p. 166, 2020.
X. Gao, Zhao, J., Han, G., Zhang, Y., Dong, X., Cao, L., Wang, Q., Moulton, H. M., and Yin, H., “Effective Dystrophin Restoration by a Novel Muscle-Homing Peptide-Morpholino Conjugate in Dystrophin-Deficient mdx Mice.”, Mol Ther, vol. 28, no. 10, pp. 2299-2301, 2020.
L. Cao, Han, G., Lin, C., Gu, B., Gao, X., Moulton, H. M., Seow, Y., and Yin, H., “Erratum: Fructose Promotes Uptake and Activity of Oligonucleotides with Different Chemistries in a Context-Dependent Manner in Mice.”, Mol Ther Nucleic Acids, vol. 22, pp. 1040-1042, 2020.
H. Yin, Moulton, H. M., Betts, C., Merritt, T., Seow, Y., Ashraf, S., Wang, Q., Boutilier, J., and Wood, M. J. A., “Functional Rescue of Dystrophin-Deficient mdx Mice by a Chimeric Peptide-PMO.”, Mol Ther, vol. 28, no. 10, pp. 2297-2298, 2020.
K. Rosenke, Leventhal, S., Moulton, H. M., Hatlevig, S., Hawman, D., Feldmann, H., and Stein, D. A., “Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers.”, bioRxiv, 2020.
D. Bestle, Heindl, M. Ruth, Limburg, H., van, T. Van Lam, Pilgram, O., Moulton, H. M., Stein, D. A., Hardes, K., Eickmann, M., Dolnik, O., Rohde, C., Klenk, H. - D., Garten, W., Steinmetzer, T., and Böttcher-Friebertshäuser, E., “TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.”, Life Sci Alliance, vol. 3, no. 9, 2020.
2019
L. Louis Seifert, Si, C., Saha, D., Sadic, M., de Vries, M., Ballentine, S., Briley, A., Wang, G., Valero-Jimenez, A. M., Mohamed, A., Schaefer, U., Moulton, H. M., García-Sastre, A., Tripathi, S., Rosenberg, B. R., and Dittmann, M., “The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response.”, PLoS Pathog, vol. 15, no. 11, p. e1007634, 2019.
H. Yin, Moulton, H. M., Betts, C., Seow, Y., Boutilier, J., Iverson, P. L., and Wood, M. J. A., “A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice.”, Hum Mol Genet, vol. 28, no. 4, p. 699, 2019.
G. Han, Gu, B., Lin, C., Ning, H., Song, J., Gao, X., Moulton, H. M., and Yin, H., “Hexose Potentiates Peptide-Conjugated Morpholino Oligomer Efficacy in Cardiac Muscles of Dystrophic Mice in an Age-Dependent Manner.”, Mol Ther Nucleic Acids, vol. 18, pp. 341-350, 2019.
H. Limburg, Harbig, A., Bestle, D., Stein, D. A., Moulton, H. M., Jaeger, J., Janga, H., Hardes, K., Koepke, J., Schulte, L., Koczulla, A. Rembert, Schmeck, B., Klenk, H. - D., and Böttcher-Friebertshäuser, E., “TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes.”, J Virol, vol. 93, no. 21, 2019.
2018
X. Gao, Ran, N., Dong, X., Zuo, B., Yang, R., Zhou, Q., Moulton, H. M., Seow, Y., and Yin, H., “Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy.”, Sci Transl Med, vol. 10, no. 444, 2018.
J. D. Lykins, Filippova, E. V., Halavaty, A. S., Minasov, G., Zhou, Y., Dubrovska, I., Flores, K. J., Shuvalova, L. A., Ruan, J., Bissati, K. El, Dovgin, S., Roberts, C. W., Woods, S., Moulton, J. D., Moulton, H. M., McPhillie, M. J., Muench, S. P., Fishwick, C. W. G., Sabini, E., Shanmugam, D., Roos, D. S., McLeod, R., Anderson, W. F., and Ngô, H. M., “CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in .”, Front Cell Infect Microbiol, vol. 8, p. 352, 2018.
J. Kim, Clark, K., Barton, C., Tanguay, R., and Moulton, H. M., “A Novel Zebrafish Model for Assessing In Vivo Delivery of Morpholino Oligomers.”, Methods Mol Biol, vol. 1828, pp. 293-306, 2018.
2017
G. Chow, Morcos, P. A., and Moulton, H. M., “Aggregation and Disaggregation of Morpholino Oligomers in Solution.”, Methods Mol Biol, vol. 1565, pp. 31-38, 2017.
Y. Echigoya, Nakamura, A., Nagata, T., Urasawa, N., Lim, K. Rowel Q., Trieu, N., Panesar, D., Kuraoka, M., Moulton, H. M., Saito, T., Aoki, Y., Iversen, P., Sazani, P., Kole, R., Maruyama, R., Partridge, T., Takeda, S. 'ichi, and Yokota, T., “Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy.”, Proc Natl Acad Sci U S A, vol. 114, no. 16, pp. 4213-4218, 2017.
H. M. Moulton and JD, M., Morpholino Oligomers: Methods and Protocols. Methods in Molecular Biology. Humana Press, 2017.

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