Clinical Trials

The Lois Bates Acheson Veterinary Teaching Hospital conducts clinical trials in conjunction with research on disease, diagnosis, and treatment of animals.*

The hospital is a member of the Comparative Oncology Trials Consortium (COTC), a network of twenty academic oncology centers, centrally managed by the National Institute of Health, that design and conduct clinical trials in dogs with cancer in order to assess new therapies.

The following are current, open clinical trials that are seeking participants.

Subaortic Stenosis Study

Dogs with subaortic stenosis are at increased risk for sudden death, and the benefits of standard therapy with Atenolol are unclear. The OSU Cardiology service is performing a study comparing the short-term effects of Atenolol and Sotalol on ventricular function, heart rate, and arrhythmias. We are recruiting young dogs with left basilar systolic murmurs for evaluation. Research funding supports much of the expense (~$650). Eligible dogs and owners are expected to pay exam fees (~$15 per visit). Study participants will be evaluated at 0, 2, and 5 weeks.

Questions? Please contact Dr. Katherine Scollan or Dr. Nicole LeBlanc: 541-737-4812.

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Study

Dogs with ARVC are at increased risk for sudden death, and some also develop systolic dysfunction which may progress to congestive heart failure. Sotalol is commonly used to treat arrhythmias in dogs with ARVC. However, the inotropic effects of sotalol have not been well-evaluated in dogs, and a reduction in contractility could precipitate heart failure in dogs affected with systolic dysfunction. The OSU Cardiology is performing a study evaluating the effects of Sotalol on systolic function in normal dogs and dogs with ARVC. We are recruiting adult Boxers (>4 years of age or with a clinical suspicion of arrhythmias) for screening for ARVC. Dogs who meet the criteria for ARVC on initial Holter monitor, and without echocardiographic evidence of overt left or right ventricular dysfunction, will be enrolled. Research funding supports much of the expense (~$265). Owners are expected to pay for Holter monitoring (~$300 x2) to establish the diagnosis and evaluate the response to anti-arrhythmic therapy. Study participants will be evaluated at 0 and 2 weeks.

Questions? Please contact Dr. Katherine Scollan or Dr. Nicole LeBlanc: 541-737-4812.   

Canine Skin Tumor Study

The Canine Skin & SQ Tumor Surgical Margin Study now has ADDITIONAL FUNDING Available! Client-owned dogs with a Mast Cell Tumor receive FREE staging, and will receive up to $1200 discount/dog. This includes an abdominal ultrasound, CT of the abdomen, liver and spleen FNA/cytology, and a discount on surgical fees.  Client-owned dogs with a non-Mast Cell Tumor (other cutaneous or subcutaneous malignant tumor) do not receive free staging; however, still can receive up to $700 discount/dog. Exclusion criteria includes pre-operative prednisone or chemotherapy. Partial exclusion criteria (may not qualify for all discounts but still will receive some financial incentives) includes previous surgical excision of the tumor, immune-mediated disease, coagulopathy, and/or an endocrinopathy.

This study is aimed at defining, 1) the best method to determine if a tumor was completely resected, and 2) if CT is better than ultrasound for staging of Mast Cell Tumors. Study dogs all receive standard-of-care treatment do not undergo experimental procedures.  If you are a dog owner interested in participation, please schedule an appointment with the Small Animal Oncology Service or Soft Tissue Surgery Service at 541-737-4812.

Questions? Please contact Dr. Milovancev (milan.milovancev@oregonstate.edu; 541-737-3527) or Dr. Bracha (shay.bracha@oregonstate.edu; 541-737-4844).

Cruciate Injuries in Purebred Labrador Retrievers

In partnership with the University of Wisconsin, OSU is collecting data for a research study on cruciate injuries in purebred Labrador Retrievers. Currently seeking participants in one of two categories:
   1. Over 8 years old with NO cruciate disease
   2. Under 8 years old WITH cruciate disease
Exam and radiographs will take about one hour and the dog will not be sedated. There is no cost. To participate, contact april.darby@oregonstate.edu by August 15, 2014. More Information.

Omental Graft in Miniature and Toy Breed Dogs with Naturally Occurring Radius/Ulna Fractures

Currently recruiting owners of miniature and toy breed dogs with mid-diaphyseal to distal radial fractures who are considering internal fixation treatment for those fractures. The trial will determine the efficacy of an omental graft in addition to a plate and screw fixator. Surgery and other costs are provided by an American College of Veterinary Surgery grant at no cost to owners. Read more. 

Canine Shoulder Injury Study

Currently recruiting dogs suspected of having an injury of the supraspinatus muscle of one or both shoulder joints. Dogs with a suspected injury will be clinically evaluated, and an ultrasound and MRI of the diseased shoulder joint will be performed. All evaluation costs and imaging costs of dogs enrolled in the study is free of charge. For more information about the study or if you would like to enroll a patient in the study, please contact Dr. Susanne Stieger-Vanegas: susanne.stieger@oregonstate.edu, or Dr. Wendy Baltzer: wendy.baltzer@oregonstate.edu. More information.

Recently Completed Clinical Trials

Canine Laryngeal Paralysis Study

Feline Hyperthyroidism Study
A study on CT imaging of the thyroid in awake cats. Completed June 2014. Abstract.

Feline Injection Site Sarcoma Study
A study of cats affected by, or suspected to be affected by, an injection site sarcoma. Completed June 2014. Abstract.

Platelet-Rich Plasma (PRP) Injection for Dogs with Hip Osteoarthritis

Giant Breed Growth Plate Study
Evaluation of bone development in large and giant breed dogs. Abstract.

 

*All clinical trials in the Lois Bates Acheson Veterinary Teaching Hospital undergo prior review and approval by IACUC.