Ling Jin

Professor, Virology

My lab is interested in understanding of the mechanism of viral diseases and virus evolution. Latency of herpesviruses is the main focus of research in my laboratory. My lab uses several different herpesviruses to study the mechanism of herpes virus latency-reactivation cycles, the pathogenesis of herpes viruses, such as Herpes Simplex Virus 1 (HSV-1), Herpes Simplex Virus 2 (HSV-2), Leporid herpesvirus 4 (LHV-4), Koi herpesvirus (KHV) and other animal herpes viruses, and host- virus interaction in central nervous system. In addition, my lab in interested in anti-viral drug development, new emerging viral disease diagnosis, such as deer pox virus, deer adenovirus, goldfish tumor virus. Currently, we have research projects on HSV, LHV-4, KHV, Bovine Herpes Virus 1 (BHV-1), goldfish tumor virus, and deer adenovirus.

Research/Career Interests: 
Pathogenesis of herpes virus infected animal disease
Host and virus interaction in central nervous system
Mechanism of herpes virus latency-reactivation cycles
Anti-viral drug development
New emerging viral diseases
Viral disease diagnosis

Education and Professional Training: 

1999: PhD. University of Illinois at Urbana-Champaign
1989:  MS. Nanjing Agricultural University, Department of Microbiology

Professional Organizations: 

American Society for Virology (Full membership)
American Association for the Advancement of Science
Phi Zeta-honorary Society of Veterinary Medicine
Gamma Sigma Delta-honorary Society of Agriculture, Illinois

Selected Publications: 

Jin L, Perng GC, Mott KR, Osorio N, Naito J, Brick D, Carpenter D, Jones C, Wechsler SL. 2004. Replacement of LAT by the well characterized anti-apoptosis gene, cpIAP, results in a high wild type HSV-1 reactivation phenotype. Manuscript

Henderson G, Peng W, Jin L, Perng GC, Nesburn AB, Wechsler SL, Jones C. Regulation of caspase 8- and caspase 9-induced apoptosis by the herpes simplex virus type 1 latency-associated transcript. J Neurovirol. 2002;8(Suppl 2):103-11.

Jin L. 1999. Pseudorabies Virus latency associated transcript gene: Expression and Regulation, and role in the establishment of latency in swine. Jin, UMI, Ann Arbor.

Weigel RM, Scherba G, Wiemers J, Siegel AM, Austin CC, Jin L, Bowman L, Johnston NA. 1997. Application of quantitative methods and molecular biological techniques to investigation of the spread of Aujeszky's disease virus. Epidemiologie et Sante Animale 31-31: 12.17.1-12.17.2.

Jin L, Schnitzlein WM, Scherba G. 1995. Establishment of latency in the natural host animal by Aujeszky's disease (pseudorabies) virus lacking the putative LAT gene promoter. In: Advances in Swine in Biomedical Research, Vol. 1, M.E. Tumbleson and L.B. Shock (eds), Plenum Publishing, NY. pp395-408.