Comparative sequences of canine and feline endothelin-1.

TitleComparative sequences of canine and feline endothelin-1.
Publication TypeJournal Article
Year of Publication2003
AuthorsBiondo AW, Wiedmeyer CE, Sisson DD, Solter PF
JournalVeterinary clinical pathology / American Society for Veterinary Clinical Pathology
Volume32
Issue4
Pagination188-94
Date Published2003
ISSN0275-6382
KeywordsAmino Acid Sequence, Animals, Antibodies, Base Sequence, Cat Diseases, Cats, Cross Reactions, Dog Diseases, Dogs, Endothelin-1, Female, Gene Amplification, Heart Diseases, Immunoassay, Male, Molecular Sequence Data, Peptide Fragments, Reverse Transcriptase Polymerase Chain Reaction, Sequence Homology, Nucleic Acid, Species Specificity
Abstract

Endothelin-1 (ET-1, "mature ET-1") is a potent vasoconstrictor peptide that is made along with "big ET-1" from its precursor, preproET-1. Increased plasma concentrations of ET-1 and big ET-1 occur with various forms of cardiovascular disease in humans. Our laboratory is investigating plasma endothelins as diagnostic tests of cardiovascular disease in dogs and cats; however, commercial immunoassays designed specifically for use in dogs and cats are limited.
Alternate JournalVet Clin Pathol