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Dystrophin-deficient muscular dystrophy in a Weimaraner.
|Title||Dystrophin-deficient muscular dystrophy in a Weimaraner.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Baltzer WI, Calise DV, Levine JM, Shelton GD, Edwards JF, Steiner JM|
|Journal||Journal of the American Animal Hospital Association|
|Date Published||2007 Jul-Aug|
|Keywords||Animals, Diagnosis, Differential, Dog Diseases, Dogs, Dystrophin, Electromyography, Immunohistochemistry, Male, Muscle, Skeletal, Muscular Dystrophy, Animal|
A 2-year-old, male Weimaraner with muscular dystrophy was presented with generalized muscle atrophy of the limbs; hypertrophy of the neck, infraspinatus, and lingual muscles; dysphagia; and regurgitation. Unilateral cryptorchidism, unilateral renal agenesis, and hiatal hernia were also detected. Spontaneous muscle activity was identified on myography. Serum creatine kinase was markedly elevated. Immunohistochemical staining for dystrophin was restricted to suspected revertant (characteristics of immaturity) fibers. Histologically, skeletal myofiber degeneration, endomysial fibrosis, and mineralization were present. Following euthanasia, necropsy revealed hypertrophy of the diaphragm and cardiac muscle fibrosis. This case of muscular dystrophy represents a slowly progressive form with organ agenesis.
|Alternate Journal||J Am Anim Hosp Assoc|