Ocular penetration of oral doxycycline in the horse.

TitleOcular penetration of oral doxycycline in the horse.
Publication TypeJournal Article
Year of Publication2005
AuthorsGilmour MA, Clarke CR, MacAllister CG, Dedeo JM, Caudell DL, Morton RJ, Pugh M
JournalVeterinary ophthalmology
Volume8
Issue5
Pagination331-5
Date Published2005 Sep-Oct
ISSN1463-5216
KeywordsAdministration, Oral, Animals, Anti-Bacterial Agents, Aqueous Humor, Area Under Curve, Biological Availability, Doxycycline, Female, Horse Diseases, Horses, Uveitis, Vitreous Body
Abstract

To investigate intraocular penetration of orally administered doxycycline in the normal equine eye and to compare intraocular and serum doxycycline concentrations. Procedures Six mares were administered doxycycline at 10 mg/kg every 12 h by nasogastric tube for 5 days. Blood, aqueous, and vitreous samples were collected on days 1 and 5. All samples were assayed for doxycycline concentrations. Aqueous and vitreous samples were also assayed for protein quantitation.

Alternate JournalVet Ophthalmol