Terbutaline pharmacokinetics in cows: preliminary data.

TitleTerbutaline pharmacokinetics in cows: preliminary data.
Publication TypeJournal Article
Year of Publication2007
AuthorsBoileau MJ, Washburn KE, Clarke CR, Streeter RN, Maxwell LK
JournalCanadian journal of veterinary research = Revue canadienne de recherche vétérinaire
Volume71
Issue1
Pagination70-3
Date Published2007 Jan
ISSN0830-9000
KeywordsAnimals, Area Under Curve, Cattle, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Female, Fluorescence, Half-Life, Injections, Intravenous, Pregnancy, Terbutaline, Tocolytic Agents
Abstract

The objective of this study was to determine the serum pharmacokinetics of terbutaline in healthy cows. In the initial experiment, terbutaline was administered once as an intravenous (i.v.) bolus to 6 near-term pregnant beef cows within 24 h after parturition at a low but therapeutically relevant dose, 5 microg/kg. A 2nd experiment was conducted in the same cows with a higher dose, 0.5 mg/kg, but an otherwise similar experimental design. The serum concentration of terbutaline was determined by means of high-performance liquid chromatography with fluorescence detection in both experiments. After i.v. administration of 0.5 mg/kg, the mean peak serum concentration, residence time, and half-life were 708.22 (standard deviation 509.6) ng/mL, 6.75 (3.6) min, and 6.93 (2.4) min, respectively. The results indicate that terbutaline is rapidly eliminated from the bloodstream after i.v. administration in cattle, falling below the assay's limit of detection 30 min after administration.

Alternate JournalCan. J. Vet. Res.