TitleAntibiotic resistance in Chlamydiae.
Publication TypeJournal Article
Year of Publication2010
AuthorsSandoz, KM, Rockey, DD
JournalFuture Microbiol
Date Published2010 Sep
KeywordsAnimals, Anti-Bacterial Agents, Cats, Chlamydia, Chlamydia Infections, Drug Resistance, Bacterial, Humans, Microbial Sensitivity Tests, Phenotype, Recombination, Genetic, Transformation, Bacterial

There are few documented reports of antibiotic resistance in Chlamydia and no examples of natural and stable antibiotic resistance in strains collected from humans. While there are several reports of clinical isolates exhibiting resistance to antibiotics, these strains either lost their resistance phenotype in vitro, or lost viability altogether. Differences in procedures for chlamydial culture in the laboratory, low recovery rates of clinical isolates and the unknown significance of heterotypic resistance observed in culture may interfere with the recognition and interpretation of antibiotic resistance. Although antibiotic resistance has not emerged in chlamydiae pathogenic to humans, several lines of evidence suggest they are capable of expressing significant resistant phenotypes. The adept ability of chlamydiae to evolve to antibiotic resistance in vitro is demonstrated by contemporary examples of mutagenesis, recombination and genetic transformation. The isolation of tetracycline-resistant Chlamydia suis strains from pigs also emphasizes their adaptive ability to acquire antibiotic resistance genes when exposed to significant selective pressure.

Alternate JournalFuture Microbiol
PubMed ID20860486
PubMed Central IDPMC3075073
Grant ListR21 AI088540 / AI / NIAID NIH HHS / United States
R21 AI088540-01 / AI / NIAID NIH HHS / United States
RC1 AI086469 / AI / NIAID NIH HHS / United States
RC1 AI086469-01 / AI / NIAID NIH HHS / United States