Title | A case of canine renal lymphoma of granular lymphocytes with severe polycythemia. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Kotb, S, Allende, C, T O'Neill, W, Bruckner, K, de Morais, HAutran, Gordon, JM, Curran, KM, Russell, DS, Stieger-Vanegas, SM, Johns, JL |
Journal | BMC Vet Res |
Volume | 17 |
Issue | 1 |
Pagination | 163 |
Date Published | 2021 Apr 14 |
ISSN | 1746-6148 |
Abstract | BACKGROUND: Renal lymphoma in dogs is rare and has a poor prognosis. Granular lymphocyte morphology is rarely reported in canine renal lymphoma. Mild to moderate polycythemia is reported in a number of canine renal lymphoma cases. CASE PRESENTATION: A 10-year-old Labrador retriever presented to a university veterinary teaching hospital after a 1-month history of polyuria, polydipsia, and pollakiuria and a 2-week history of abdominal distention, lethargy, and increased respiratory effort. Abdominal ultrasound showed a wedge-shaped to rounded, heterogeneously hypoechoic mass lesion in the left kidney. Cytologic analysis of a percutaneous aspirate of the mass was consistent with lymphoma of granular lymphocytes. Severe polycythemia (hematocrit 0.871) was noted on a complete blood cell count. Clonality analysis identified a clonally rearranged T-cell receptor (TCR) gene and immunohistochemical staining was CD3+, CD79a- and CD11d+, supporting cytotoxic T-cell lymphoma. CONCLUSIONS: To our knowledge, this is the first report of renal cytotoxic T-cell lymphoma with severe polycythemia in a dog. Severe polycythemia and renal cytotoxic T-cell lymphoma are both rare in dogs; this report adds to the body of knowledge on these conditions. |
DOI | 10.1186/s12917-021-02854-5 |
Alternate Journal | BMC Vet Res |
PubMed ID | 33853604 |
PubMed Central ID | PMC8048226 |