TitleChemiosmotic mechanism of antimicrobial activity of Ag(+) in Vibrio cholerae.
Publication TypeJournal Article
Year of Publication2002
AuthorsDibrov, P, Dzioba, J, Gosink, KK, Häse, CC
JournalAntimicrobial agents and chemotherapy
Date Published2002 Aug
KeywordsVibrio cholerae

Although the antimicrobial effects of silver salts were noticed long ago, the molecular mechanism of the bactericidal action of Ag(+) in low concentrations has not been elucidated. Here, we show that low concentrations of Ag(+) induce a massive proton leakage through the Vibrio cholerae membrane, which results in complete deenergization and, with a high degree of probability, cell death.