Title | Chemiosmotic mechanism of antimicrobial activity of Ag(+) in Vibrio cholerae. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Dibrov, P, Dzioba, J, Gosink, KK, Häse, CC |
Journal | Antimicrobial agents and chemotherapy |
Volume | 46 |
Issue | 8 |
Pagination | 2668-70 |
Date Published | 2002 Aug |
Keywords | Vibrio cholerae |
Abstract | Although the antimicrobial effects of silver salts were noticed long ago, the molecular mechanism of the bactericidal action of Ag(+) in low concentrations has not been elucidated. Here, we show that low concentrations of Ag(+) induce a massive proton leakage through the Vibrio cholerae membrane, which results in complete deenergization and, with a high degree of probability, cell death. |