TitleChlamydial Antibiotic Resistance and Treatment Failure in Veterinary and Human Medicine.
Publication TypeJournal Article
Year of Publication2016
AuthorsBorel, N, Leonard, C, Slade, J, Schoborg, RV
JournalCurr Clin Microbiol Rep
Date Published2016

The are widespread pathogens of both humans and animals. infection causes blinding trachoma and reproductive complications in humans. causes human respiratory tract infections and atypical pneumonia. infection is associated with conjunctivitis, diarrhea, and failure to gain weight in domestic swine. Chlamydial infections in humans and domesticated animals are generally controlled by antibiotic treatment-particularly macrolides (usually azithromycin) and tetracyclines (tetracycline and doxycycline). Tetracycline-containing feed has also been used to limit infections and promote growth in livestock populations, although its use has decreased because of growing concerns about antimicrobial resistance development. Because Sandoz and Rockey published an elegant review of chlamydial anti-microbial resistance in 2010, we will review the following: (i) antibiotic resistance in , (ii) recent evidence for acquired resistance in human chlamydial infections, and (iii) recent non-genetic mechanisms of antibiotic resistance that may contribute to treatment failure.

Alternate JournalCurr Clin Microbiol Rep
PubMed ID27218014
PubMed Central IDPMC4845085
Grant ListC06 RR030651 / RR / NCRR NIH HHS / United States
R01 AI095637 / AI / NIAID NIH HHS / United States