Title | Chlamydial antigens colocalize within IncA-laden fibers extending from the inclusion membrane into the host cytosol. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Brown, WJ, Skeiky, YAW, Probst, P, Rockey, DD |
Journal | Infect Immun |
Volume | 70 |
Issue | 10 |
Pagination | 5860-4 |
Date Published | 2002 Oct |
ISSN | 0019-9567 |
Keywords | Antigens, Bacterial, Bacterial Proteins, Cell Division, Chlamydia, Chlamydia Infections, Chlamydia trachomatis, Chlamydophila pneumoniae, Chlamydophila psittaci, HeLa Cells, Humans, Inclusion Bodies, Microscopy, Fluorescence, Phosphoproteins |
Abstract |
Chlamydial IncA localizes to the inclusion membrane and to vesicular fibers extending away from the inclusion. Chlamydial outer membrane components, in the absence of developmental forms, are found within these fibers. This colocalization may explain how chlamydial developmental form antigens are localized outside of the inclusion within infected cells.
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DOI | 10.1128/iai.70.10.5860-5864.2002 |
Alternate Journal | Infect Immun |
PubMed ID | 12228318 |
PubMed Central ID | PMC128327 |
Grant List | R01AI48679-01 / AI / NIAID NIH HHS / United States R29AI42869 / AI / NIAID NIH HHS / United States |