TitleChronic Mycobacterium marinum infection acts as a tumor promoter in Japanese Medaka (Oryzias latipes).
Publication TypeJournal Article
Year of Publication2009
AuthorsBroussard, GW, Norris, MB, Schwindt, AR, Fournie, JW, Winn, RN, Kent, ML, Ennis, DG
JournalComp Biochem Physiol C Toxicol Pharmacol
Date Published2009 Mar
KeywordsAdenoma, Animals, Animals, Genetically Modified, Benzo(a)pyrene, Carcinogens, Carcinoma, Hepatocellular, Chronic Disease, Dose-Response Relationship, Drug, Liver Neoplasms, Experimental, Mutagenicity Tests, Mycobacterium Infections, Nontuberculous, Mycobacterium marinum, Oryzias

An accumulating body of research indicates there is an increased cancer risk associated with chronic infections. The genus Mycobacterium contains a number of species, including M. tuberculosis, which mount chronic infections and have been implicated in higher cancer risk. Several non-tuberculosis mycobacterial species, including M. marinum, are known to cause chronic infections in fish and like human tuberculosis, often go undetected. The elevated carcinogenic potential for fish colonies infected with Mycobacterium spp. could have far reaching implications because fish models are widely used to study human diseases. Japanese medaka (Oryzias latipes) is an established laboratory fish model for toxicology, mutagenesis, and carcinogenesis; and produces a chronic tuberculosis-like disease when infected by M. marinum. We examined the role that chronic mycobacterial infections play in cancer risk for medaka. Experimental M. marinum infections of medaka alone did not increase the mutational loads or proliferative lesion incidence in all tissues examined. However, we showed that chronic M. marinum infections increased hepatocellular proliferative lesions in fish also exposed to low doses of the mutagen benzo[a]pyrene. These results indicate that chronic mycobacterial infections of medaka are acting as tumor promoters and thereby suggest increased human risks for cancer promotion in human populations burdened with chronic tuberculosis infections.

Alternate JournalComp Biochem Physiol C Toxicol Pharmacol
PubMed ID18929684
PubMed Central IDPMC2700008
Grant ListR21 AI055964 / AI / NIAID NIH HHS / United States
P30 ES003850 / ES / NIEHS NIH HHS / United States
P30 ES03850 / ES / NIEHS NIH HHS / United States
RR11733 / RR / NCRR NIH HHS / United States
5R21AI055964-01 / AI / NIAID NIH HHS / United States
R24 RR011733 / RR / NCRR NIH HHS / United States
R21 AI055964-02 / AI / NIAID NIH HHS / United States