TitleClostridium perfringens tpeL is expressed during sporulation.
Publication TypeJournal Article
Year of Publication2011
AuthorsParedes-Sabja, D, Sarker, N, Sarker, MR
JournalMicrobial pathogenesis
Date Published2011 Nov
KeywordsBacterial, Spores

Clostridium perfringens TpeL belongs to the family of large clostridial toxins. Although recent studies demonstrated the expression of tpeL during vegetative growth nothing is known about tpeL expression during sporulation. Our current study demonstrated that tpeL: (i) is also expressed during sporulation; (ii) expression is dependent on the master regulator of sporulation, Spo0A, and the sporulation-specific sigma factor, SigE; and (iii) is localized to the mother cell compartment of the sporulating cell. In summary, these results indicate that TpeL is a sporulation-regulated C. perfringens toxin.