TitleCytokinesis is blocked in mammalian cells transfected with Chlamydia trachomatis gene CT223.
Publication TypeJournal Article
Year of Publication2009
AuthorsAlzhanov, DT, Weeks, SK, Burnett, JR, Rockey, DD
JournalBMC microbiology
Date Published2009

The chlamydiae alter many aspects of host cell biology, including the division process, but the molecular biology of these alterations remains poorly characterized. Chlamydial inclusion membrane proteins (Incs) are likely candidates for direct interactions with host cell cytosolic proteins, as they are secreted to the inclusion membrane and exposed to the cytosol. The inc gene CT223 is one of a sequential set of orfs that encode or are predicted to encode Inc proteins. CT223p is localized to the inclusion membrane in all tested C. trachomatis serovars.