TitleDifferences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta.
Publication TypeJournal Article
Year of Publication2021
AuthorsTaggart-Murphy, L, Alama-Bermejo, G, Dolan, BP, Takizawa, F, Bartholomew, J
JournalDev Comp Immunol
Date Published2021 01

Two genotypes of the intestinal parasite Ceratonova shasta infect Oncorhynchus mykiss: genotype 0 results in a chronic infection with low mortality while genotype IIR causes disease with high mortality. We determined parasite load and the relative expression of six immune factors (IgT, IgM, IL-6, IL-8, IL-10, IFNG) in fish infected with either genotype over 29 days post-exposure. In genotype IIR infections the host responded with upregulation of inflammatory and regulatory cytokines. In contrast, genotype 0 infection did not elicit an inflammatory response and expression of IFNG and IL-10 was lower. Antibody expression was upregulated in both infections but appeared to have limited efficacy in the virulent genotype IIR infections. Histologically, in genotype 0 infections the parasite migrated through the tissue layers causing inflammation but minimal damage to the mucosal epithelium, which contrasts with the severe pathology found in genotype IIR infections.

Alternate JournalDev Comp Immunol
PubMed ID32846161
PubMed Central IDPMC7655565
Grant ListR01 GM085207 / GM / NIGMS NIH HHS / United States