Title | Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Taggart-Murphy, L, Alama-Bermejo, G, Dolan, BP, Takizawa, F, Bartholomew, J |
Journal | Dev Comp Immunol |
Volume | 114 |
Pagination | 103829 |
Date Published | 2021 01 |
ISSN | 1879-0089 |
Abstract | Two genotypes of the intestinal parasite Ceratonova shasta infect Oncorhynchus mykiss: genotype 0 results in a chronic infection with low mortality while genotype IIR causes disease with high mortality. We determined parasite load and the relative expression of six immune factors (IgT, IgM, IL-6, IL-8, IL-10, IFNG) in fish infected with either genotype over 29 days post-exposure. In genotype IIR infections the host responded with upregulation of inflammatory and regulatory cytokines. In contrast, genotype 0 infection did not elicit an inflammatory response and expression of IFNG and IL-10 was lower. Antibody expression was upregulated in both infections but appeared to have limited efficacy in the virulent genotype IIR infections. Histologically, in genotype 0 infections the parasite migrated through the tissue layers causing inflammation but minimal damage to the mucosal epithelium, which contrasts with the severe pathology found in genotype IIR infections. |
DOI | 10.1016/j.dci.2020.103829 |
Alternate Journal | Dev Comp Immunol |
PubMed ID | 32846161 |
PubMed Central ID | PMC7655565 |
Grant List | R01 GM085207 / GM / NIGMS NIH HHS / United States |