TitleEffect of acepromazine, diazepam, fentanyl-droperidol, and oxymorphone on gastroesophageal sphincter pressure in healthy dogs.
Publication TypeJournal Article
Year of Publication1987
AuthorsHall, JA, Magne, ML, Twedt, DC
JournalAm J Vet Res
Date Published1987 Apr
KeywordsAcepromazine, Analgesics, Opioid, Animals, Diazepam, Dogs, Droperidol, Drug Combinations, Esophagogastric Junction, Fentanyl, Oxymorphone, Pressure, Tranquilizing Agents

Treatment of healthy dogs with 4 commonly used psychotropic or analgesic agents significantly decreased resting gastroesophageal sphincter pressure (GESP). Acepromazine decreased GESP by 35% (P = 0.02); oxymorphone decreased GESP by 38% (P less than 0.005); diazepam decreased GESP by 42% (P = 0.005); and fentanyl-droperidol decreased GESP by 40% (P = 0.03). Therefore, esophageal manometric evaluation of gastroesophageal sphincter function should not be preceded by administration of these drugs.

Alternate JournalAm J Vet Res
PubMed ID2884907