TitleEffects of aging on NMDA and MK801 binding sites in mice.
Publication TypeJournal Article
Year of Publication1993
AuthorsMagnusson, KR, Cotman, CW
JournalBrain research
Date Published1993 Feb 26
KeywordsN-Methyl-D-Aspartate, Receptors

[3H]MK801 binding was significantly reduced in three cortical and two subcortical regions in 30-month-old C57Bl mice, as compared to 3-month-olds. NMDA binding sites showed significant reductions with aging in sixteen of nineteen brain regions. These results suggest that, in a majority of cortical and hippocampal regions, decreases in binding to NMDA sites with aging may be due to factors other than cell loss.