OREGON STATE UNIVERSITY
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| Title | Effects of aging on NMDA and MK801 binding sites in mice. |
| Publication Type | Journal Article |
| Year of Publication | 1993 |
| Authors | Magnusson, KR, Cotman, CW |
| Journal | Brain research |
| Volume | 604 |
| Issue | 1-2 |
| Pagination | 334-7 |
| Date Published | 1993 Feb 26 |
| Keywords | N-Methyl-D-Aspartate, Receptors |
| Abstract | [3H]MK801 binding was significantly reduced in three cortical and two subcortical regions in 30-month-old C57Bl mice, as compared to 3-month-olds. NMDA binding sites showed significant reductions with aging in sixteen of nineteen brain regions. These results suggest that, in a majority of cortical and hippocampal regions, decreases in binding to NMDA sites with aging may be due to factors other than cell loss. |