Title | Effects of aging on NMDA and MK801 binding sites in mice. |
Publication Type | Journal Article |
Year of Publication | 1993 |
Authors | Magnusson, KR, Cotman, CW |
Journal | Brain research |
Volume | 604 |
Issue | 1-2 |
Pagination | 334-7 |
Date Published | 1993 Feb 26 |
Keywords | N-Methyl-D-Aspartate, Receptors |
Abstract | [3H]MK801 binding was significantly reduced in three cortical and two subcortical regions in 30-month-old C57Bl mice, as compared to 3-month-olds. NMDA binding sites showed significant reductions with aging in sixteen of nineteen brain regions. These results suggest that, in a majority of cortical and hippocampal regions, decreases in binding to NMDA sites with aging may be due to factors other than cell loss. |