TitleEnemies and turncoats: bovine tuberculosis exposes pathogenic potential of Rift Valley fever virus in a common host, African buffalo (Syncerus caffer).
Publication TypeJournal Article
Year of Publication2015
AuthorsBeechler, B
Secondary AuthorsManore, CA
Tertiary AuthorsReininghaus, B
Subsidiary AuthorsO'Neal, D, Gorsich, EE, Ezenwa, VO, Jolles, AE
JournalProc Biol Sci
Volume282
Issue1805
Date Published2015 Apr 22
ISSN1471-2954
KeywordsAbortion, Veterinary, Animals, Buffaloes, Cattle, Coinfection, Disease Susceptibility, Female, Immunity, Innate, Male, Models, Theoretical, Mycobacterium bovis, Rift Valley Fever, Rift Valley fever virus, South Africa, Tuberculosis, Bovine
Abstract

The ubiquity and importance of parasite co-infections in populations of free-living animals is beginning to be recognized, but few studies have demonstrated differential fitness effects of single infection versus co-infection in free-living populations. We investigated interactions between the emerging bacterial disease bovine tuberculosis (BTB) and the previously existing viral disease Rift Valley fever (RVF) in a competent reservoir host, African buffalo, combining data from a natural outbreak of RVF in captive buffalo at a buffalo breeding facility in 2008 with data collected from a neighbouring free-living herd of African buffalo in Kruger National Park. RVF infection was twice as likely in individual BTB+ buffalo as in BTB- buffalo, which, according to a mathematical model, may increase RVF outbreak size at the population level. In addition, co-infection was associated with a far higher rate of fetal abortion than other infection states. Immune interactions between BTB and RVF may underlie both of these interactions, since animals with BTB had decreased innate immunity and increased pro-inflammatory immune responses. This study is one of the first to demonstrate how the consequences of emerging infections extend beyond direct effects on host health, potentially altering the dynamics and fitness effects of infectious diseases that had previously existed in the ecosystem on free-ranging wildlife populations.

DOI10.1098/rspb.2014.2942
Alternate JournalProc. Biol. Sci.
PubMed ID25788592
PubMed Central IDPMC4389613
Grant ListU01 GM097661 / GM / NIGMS NIH HHS / United States
U01-GM097661-01 / GM / NIGMS NIH HHS / United States