TitleEpidemiology and clinical manifestations of unique Chlamydia trachomatis isolates that occupy nonfusogenic inclusions.
Publication TypeJournal Article
Year of Publication2001
AuthorsGeisler, WM, Suchland, RJ, Rockey, DD, Stamm, WE
JournalJ Infect Dis
Date Published2001 Oct 01
KeywordsAdolescent, Adult, Bacterial Proteins, Case-Control Studies, Chlamydia Infections, Chlamydia trachomatis, Ethnic Groups, Female, Female Urogenital Diseases, Humans, Inclusion Bodies, Logistic Models, Male, Male Urogenital Diseases, Mutation, Phosphoproteins, Sexually Transmitted Diseases, Washington

Unique Chlamydia trachomatis strains characterized by multiple nonfusing inclusions were recently described. These strains lack evidence of the protein IncA in the inclusion membrane and have mutations in the incA gene. This study evaluated the epidemiology and clinical manifestations of patients infected with nonfusing mutant strains (case patients) and compared them with patients infected with wild-type fusing strains (control subjects). Both male and female case patients had fewer signs of infection than did control subjects (P=.016 and P=.019, respectively). Female case patients also had fewer symptoms of infection (P=.02). Median inclusion-forming unit (ifu) counts were lower in male and female case patients (P=.045 and P=.135, respectively). Thus, nonfusing strains of C. trachomatis more often produce subclinical infections than do normal fusing strains and have lower median ifu counts. From a prevention perspective, the data underscore the importance of screening programs to detect and treat inapparent C. trachomatis infection.

Alternate JournalJ Infect Dis
PubMed ID11528595
Grant ListAI-31448 / AI / NIAID NIH HHS / United States
AI-48769 / AI / NIAID NIH HHS / United States